Baseline characteristics and outcomes in patients who completed the procedure under monitored anethesia care (MAC) versus those who required conversion to general anesthesia (GA)
| MAC n=1651 | Converted to GA n=26 | P value | |
| Demographic and clinical characteristics, n (%) | |||
| Age (years), median (IQR) | 65 (55–76) | 63.5 (54.25–76) | 0.87 |
| Female | 799 (48.4) | 11 (42.3) | 0.54 |
| Ethnic background | |||
| White | 738 (44.7) | 12 (46.2) | |
| Black/African American | 684 (41.4) | 12 (46.2) | |
| Hispanic | 60 (3.6) | 1 (3.8) | |
| Asian | 37 (2.2) | 0 (0) | |
| Other | 132 (8) | 1 (3.8) | 0.95 |
| BMI (kg/m2), median (IQR) | 27.90 (24.20–32.28) | 28.05 (23.90–34.41) | 0.82 |
| BMI (kg/m2) | n=1455 | n=24 | |
| >30 | 517 (35.5) | 9 (37.5) | |
| ≤30 | 938 (64.5) | 15 (62.5) | 0.84 |
| Hypertension | 1217 (73.7) | 23 (88.5) | 0.11 |
| Diabetes mellitus | 560 (33.9) | 12 (46.2) | 0.19 |
| Smoking | 338 (20.9) | 7 (28) | 0.38 |
| Hypercholesterolemia | 554 (33.6) | 13 (50) | 0.08 |
| Atrial fibrillation | 537 (32.5) | 11 (42.3) | 0.92 |
| White blood cell count (x109/L), median (IQR) | 8.3 (6.4–10.8) | 9 (7.6–11.45) | 0.18 |
| Ejection fraction (%), median (IQR) | 55 (50–60) | 57.5 (50–65) | 0.35 |
| Baseline NIHSS score, median (IQR) | 16 (11–21) | 13 (9.75–18.5) | 0.18 |
| Baseline NIHSS score | n=1640 | n=26 | |
| >15 | 888 (54.1) | 11 (42.3) | |
| ≤15 | 752 (45.9) | 15 (57.7) | 0.23 |
| Site of occlusion | |||
| Anterior circulation | |||
| Cervical ICA | 71 (4.3) | 1 (3.8) |
0.06 |
| Intracranial ICA | 247 (15) | 2 (7.7) | |
| MCA-M1/M2 | 1193 (72.3) | 17 (65.4) | |
| MCA-M3 | 41 (2.5) | 1 (3.8) | |
| ACA | 41 (2.5) | 1 (3.8) | |
| Posterior circulation | 58 (3.5) | 4 (15.4) | |
| Stroke side | |||
| Left | 849 (51.4) | 10 (38.5) | 0.018 |
| Right | 744 (45.1) | 12 (46.2) | |
| ASPECTS median (IQR) | 8 (7–10) | 9 (6.5–10) | 0.45 |
| rCBF <30% mL, median (IQR) | 6 (0–22.1) | 9.55 (0–34.15) | 0.28 |
| Tandem occlusion | 169 (10.2) | 1 (3.8) | 0.51 |
| Last known well to puncture (min), median (IQR) | 368.5 (225–675) | 458 (222–731) | 0.68 |
| Procedure duration (min), median (IQR) | 53 (34–80) | 101.5 (72.5–130) | <0.001 |
| IV-tPA | 576 (34.9) | 8 (30.8) | 0.66 |
| Outcome n (%) | |||
| Successful reperfusion (mTICI 2b–3) | 1579 (95.6) | 23 (88.5) | 0.11 |
| sICH | 65 (3.9) | 0 (0) | 0.62 |
| 90-day mRS 0–2 | 661/1282 (51.6) | 6/21 (28.6) | 0.037 |
| 90-day mortality | 233/1282 (18.2) | 6/21 (28.6) | 0.22 |
ACA, anterior cerebral artery; ASPECTS, Alberta Stroke Program Early CT Score; BMI, body mass index; ICA, internal carotid artery; IV-tPA, intravenous tissue plasminogen activator; MCA, middle cerebral artery; mRS, modified Rankin Scale; rCBF, relative cerebral blood flow; NIHSS score, National Institute of Health Stroke Scale score; sICH, symptomatic intracranial hemorrhage.