Table 1

Clinical characteristics of the groups by baseline ischemic core volume in the full cohort

Group (baseline ischemic core volume)Group AGroup BGroup C
Characteristic70–100 mL100–130 mL>130 mL
MT (n=31)SMT (n=21)P value* MT (n=14)SMT (n=22)P value* MT (n=4)SMT (n=65)P value*
Female11 (36)16 (76)<0.057 (50)9 (41)0.594 (100)44 (68)<0.05
Age (years)76 (71–85)79 (67–87)0.5880 (71–85)77 (71–84)0.8377 (65–81)84 (77–87)0.09
Prestroke mRS score0 (0–2)0 (0–2)0.790 (0–2)0 (0–4)0.551 (0–2)0 (0–3)0.98
Medical history
 Hypertension19 (61)14 (67)0.6910 (71)15 (68)0.844 (100)45 (69)0.19
 Dyslipidemia11 (36)9 (43)0.596 (43)8 (36)0.703 (75)27 (42)0.19
 Diabetes mellitus5 (16)2 (10)0.494 (29)7 (32)0.841 (25)9 (14)0.54
 Current smoking8 (26)1 (5)0.053 (21)5 (23)0.932 (50)6 (9)<0.05
 Ischemic stroke3 (10)3 (14)0.615 (36)9 (41)0.762 (50)11 (17)0.10
 Atrial fibrillation21 (68)9 (43)0.0812 (86)15 (68)0.243 (75)53 (82)0.75
Systolic blood pressure on admission (mmHg)148 (124–165)144 (136–179)0.44151 (131–175)160 (148–182)0.39150 (139–164)159 (142–176)0.57
Baseline NIHSS score21 (18–24)20 (16–26)0.7924 (20–28)23 (18–26)0.7629 (24–36)26 (21–31)0.26
Serum glucose (mmol/L)6.56 (5.78–7.67)6.94 (6.67–8.50)0.107.56 (6.61–10.72)7.33 (7.00–10.22)0.598.83 (7.17–10.67)7.44 (6.17–9.11)0.30
Baseline DWI-ASPECTS5 (4–6)4 (3–5)<0.056 (4–6)3 (1–5)<0.053 (3–6)2 (1–3)<0.05
Baseline DWI ischemic core volume (mL)80 (74–87)85 (77–91)0.06107 (101–117)113 (107–124)0.14178 (175–194)182 (150–210)0.82
Occluded artery
 ICA13 (42)7 (33)0.536 (43)9 (41)0.911 (25)43 (66)0.10
 MCA M110 (32)8 (38)0.665 (36)11 (50)0.401 (25)16 (25)0.11
 MCA M22 (7)4 (19)0.1601 (5)0.421 (25)1 (2)<0.05
Tandem occlusion6 (19)2 (10)0.363 (21)1 (5)0.1700--
Multivessel occlusion00--00--1 (25)5 (8)0.23
Time logistics
 Onset-to-hospital arrival time (min)75 (38–264)330 (47–639)<0.0567 (58–173)367 (150–740)<0.0550 (38–81)379 (102–719)<0.05
 Onset-to-imaging time (min)94 (57–305)357 (75–669)<0.0594 (81–199)400 (191–758)<0.0577 (61–98)434 (147–815)<0.05
Treatment profile
 Intravenous thrombolysis13 (42)1 (5)<0.054 (29)1 (5)<0.052 (50)1 (2)<0.05
Stroke causative mechanism<0.050.380.87
 Large artery atherosclerosis5 (16)1 (5)03 (14)02 (3)
 Cardioembolism24 (77)11 (52)10 (71)15 (71)4 (100)55 (85)
 Other08 (38)2 (14)2 (10)07 (11)
 Unknown2 (7)1 (5)2 (14)1 (5)01 (2)
  • Data are presented as number (%) or median (IQR).

  • *Fisher’s exact test.

  • CT, computed tomography; DWI, diffusion-weighted imaging; DWI-ASPECTS, Diffusion-Weighted Imaging-Alberta Stroke Program Early Computed Tomographic Score; ICA, internal carotid artery; MCA, middle cerebral artery; mRS, modified Rankin Scale; MT, mechanical thrombectomy; NIHSS, National Institutes of Health Stroke Scale; SMT, standard medical treatment.