Trial | TENSION | LASTE | TESLA | RESCUE-Japan LIMIT | SELECT-2 | ANGEL-ASPECT |
Official title | Efficacy and Safety of Thrombectomy in Stroke With Extended Lesion and Extended Time Window | Large Stroke Therapy Evaluation - ASPECTS 0–5 | Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke | Randomized Controlled Trial of Endovascular Therapy for Acute Large Vessel Occlusion With Large Ischemic Core | A Randomized Controlled Trial to Optimize Patient’s Selection for Endovascular Treatment in Acute Ischemic Stroke | Study of EVT in Acute Anterior Circulation LVO Patients with a largE infarCT core |
NCT number | NCT03094715 | IN EXTREMIS | NCT03805308 | NCT03702413 | NCT03876457 | NCT04551664 |
Country | Austria, Canada, Czechia, Denmark, France, Germany, Norway, Slovakia, Spain | USA, Europe | United States | Japan | United States (Canada,Europe) | China |
Imaging inclusion criteria | NCCT or DWI ASPECTS 3–5 | NCCT or DWI ASPECTS 0–5 | NCCT ASPECTS 2–5 | CT-ASPECTS 3–5 or DWI-ASPECTS 3–5; | 1. ASPECTS ≥6andcore ≥50 cc 2. ASPECTS 3–5andcore ≥50 cc 3. ASPECTS 3–5andcore <5 0cc | 1. ASPECTS 3–5 2. ASPECTS >5 (>6 hour) and core 70–100 cc 3. ASPECT <3 and core 70–100 cc |
NIHSS score | <26 | >5 | >6 | ≥6 | ≥6 | 6–30 |
Age (years) | >18 | 18–80 | 18–85 | >18 | 18–85 | 18–80 |
Time | <12 hour LSW | <6.5 hour LKW | Random <24 hour | Random <6 hour LKW, 6–24 FLAIR (-) | Treat <24 hour (0–12vs6–24) | Random <24 hour |
Primary outcome | mRS score shift analysis | mRS score at 90& and 180 days | Utility-weighted 90-day mRS score | mRS score 0–3 at 90 days | Shift on 90-day mRS score | mRS score at 90 days |
Actual study start date | July 20, 2018 | – | July 16, 2019 | November 2018 | October 11, 2019 | September 28, 2020 |
Estimated primary completion date | August 31, 2020 | – | July 16, 2022 | November 2020 | May 1, 2021 | November 2022 |
Core:rCBF <30% on CT perfusion or ADC<620; Information source:https://clinicaltrials.gov. and Website.
ADC, apparent diffusion coefficient; ASPECTS, Alberta Stroke Program Early CT Score; DWI, diffusion-weighted imaging; FLAIR, fluid attenuated inversion recovery; LKW, last known well; LSW, last seen well; LVO, large vessel occlusion; mRS, modified Rankin Scale; NCCT, non-contrast CT; rCBF, relative cerebral blood flow.