Multivariable analysis of risk factors of unexplained early neurological deterioration in the medical management arm
| Characteristic | OR | 95% LCL | 95% UCL | P value |
| Age (years) | 0.99 | 0.95 | 1.03 | 0.63 |
| Age (years)* | 1.03 | 0.99 | 1.07 | 0.28 |
| NIHSS at baseline | 0.95 | 0.86 | 1.06 | 0.29 |
| NIHSS at baseline* | 0.96 | 0.83 | 1.11 | 0.63 |
| Glucose | 1.03 | 1.00 | 1.05 | 0.03 |
| Glucose* | 0.98 | 0.95 | 1.00 | 0.04 |
| Systolic BP | 0.99 | 0.97 | 1.02 | 0.56 |
| Systolic BP* | 1.01 | 0.99 | 1.04 | 0.32 |
| Diabetes mellitus | 1.12 | 0.56 | 2.22 | 0.83 |
| Prior stroke | 1.42 | 0.66 | 3.06 | 0.66 |
| Pre-stroke mRS | 1.27 | 0.75 | 2.14 | 0.35 |
| Site of occlusion: ICA | 1.93 | 0.60 | 6.18 | 0.37 |
| Site of occlusion: M1 | 0.72 | 0.23 | 2.28 | 0.39 |
| Site of occlusion: M2 | 0.91 | 0.21 | 3.89 | 0.61 |
| ASPECTS | 0.90 | 0.79 | 1.02 | 0.12 |
| Collateral grade | 0.85 | 0.57 | 1.26 | 0.14 |
| Onset to randomization (min) | 1.00 | 0.99 | 1.01 | 0.77 |
| Onset to randomization (min)* | 1.00 | 0.99 | 1.01 | 0.93 |
*Particular lines indicate multiple odds ratios due to spline modeling; OR calculated using patients without early neurological deterioration as reference group.
ASPECTS, Alberta Stroke Program Early CT Score; BP, blood pressure; ICA, internal carotid artery; LCL, lower confidence limits; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; UCL, upper confidence limits.