Outcomes | IVT− (n=222) | IVT+ (n=380) | Before IPTW | After IPTW* | ||
Effect size (95% CI) | P value | Effect size (95% CI) | P value | |||
Clinical outcomes | ||||||
Favorable outcome† | 99 (44.6) | 211 (55.5) | 1.55 (1.11 to 2.17) | 0.011 | 1.10 (1.02 to 1.20) | 0.016 |
Excellent outcome‡ | 61 (27.5) | 146 (38.4) | 1.64 (1.14 to 2.37) | 0.008 | 1.10 (1.02 to 1.19) | 0.014 |
90-Day mortality | 35 (15.8) | 40 (10.5) | 0.63 (0.38 to 1.03) | 0.063 | 0.96 (0.90 to 1.01) | 0.12 |
Hemorrhagic complications | ||||||
sICH | 18 (8.1) | 27 (7.1) | 0.89 (0.47 to 1.67) | 0.71 | 0.99 (0.95 to 1.04) | 0.76 |
PH2 | 16 (7.2) | 21 (5.5) | 0.77 (0.39 to 1.54) | 0.46 | 0.98 (0.95 to 1.02) | 0.45 |
24-Hour NIHSS score shift, median (IQR) | −1 (−6 to 2) | −4 (−9 to 0) | −2.5 (−4.1 to −0.9) | 0.002 | −2.1 (−3.8 to -0.5) | 0.013 |
24-Hour ASPECTS shift, median (IQR) | −1 (−3 to 0) | −1 (−3 to 0) | 0.3 (−0.1 to 0.7) | 0.16 | 0.5 (0.1 to 0.9) | 0.007 |
Procedural outcomes | ||||||
Successful reperfusion§ | 155 (69.8) | 301 (79.2) | 1.64 (1.12 to 2.40) | 0.010 | 1.11 (1.03 to 1.19) | 0.004 |
Excellent reperfusion¶ | 54 (24.3) | 118 (31.1) | 1.39 (0.56 to 2.02) | 0.085 | 1.07 (0.99 to 1.15) | 0.054 |
Procedural complications | 29 (13.1) | 48 (12.6) | 0.97 (0.59 to 1.60) | 0.92 | 0.99 (0.94 to 1.05) | 0.77 |
Values are expressed as number (%) unless otherwise indicated.
Descriptive parameters and effect sizes (Odd ratio or mean difference) were calculated after multiple imputation to handle missing values for variables included in the propensity score.
*Propensity score was calculated taking into account all variables in table 1.
†Favorable outcome defined as a 90-day mRS score of 0 to 2.
‡Defined as a 90-day mRS score of 0 to 1.
§Defined as a mTICI 2b/3.
¶Defined as a mTICI 3.
ASPECTS, Alberta Stroke Program Early CT Score; IPTW, inverse probability of treatment weighting; IVT, intravenous thrombolysis; mRS, modified Rankin Scale; mTICI, modified Thrombolysis in Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale; PH2, parenchymal hemorrhage type 2; sICH, symptomatic intracerebral hemorrhage.