Table 2

Comparisons of clinical and procedural outcomes according to intravenous thrombolysis use before and after inverse probability of treatment weighting in overall study sample (main analysis)

OutcomesIVT−
(n=222)
IVT+
(n=380)
Before IPTWAfter IPTW*
Effect size (95% CI)P valueEffect size (95% CI)P value
Clinical outcomes
 Favorable outcome†99 (44.6)211 (55.5)1.55 (1.11 to 2.17)0.0111.10 (1.02 to 1.20)0.016
 Excellent outcome‡61 (27.5)146 (38.4)1.64 (1.14 to 2.37)0.0081.10 (1.02 to 1.19)0.014
 90-Day mortality35 (15.8)40 (10.5)0.63 (0.38 to 1.03)0.0630.96 (0.90 to 1.01)0.12
 Hemorrhagic complications
 sICH18 (8.1)27 (7.1)0.89 (0.47 to 1.67)0.710.99 (0.95 to 1.04)0.76
 PH216 (7.2)21 (5.5)0.77 (0.39 to 1.54)0.460.98 (0.95 to 1.02)0.45
24-Hour NIHSS score shift, median (IQR)−1 (−6 to 2)−4 (−9 to 0)−2.5 (−4.1 to −0.9)0.002−2.1 (−3.8 to -0.5)0.013
24-Hour ASPECTS shift, median (IQR)−1 (−3 to 0)−1 (−3 to 0)0.3 (−0.1 to 0.7)0.160.5 (0.1 to 0.9)0.007
Procedural outcomes
 Successful reperfusion§155 (69.8)301 (79.2)1.64 (1.12 to 2.40)0.0101.11 (1.03 to 1.19)0.004
 Excellent reperfusion¶54 (24.3)118 (31.1)1.39 (0.56 to 2.02)0.0851.07 (0.99 to 1.15)0.054
 Procedural complications29 (13.1)48 (12.6)0.97 (0.59 to 1.60)0.920.99 (0.94 to 1.05)0.77
  • Values are expressed as number (%) unless otherwise indicated.

  • Descriptive parameters and effect sizes (Odd ratio or mean difference) were calculated after multiple imputation to handle missing values for variables included in the propensity score.

  • *Propensity score was calculated taking into account all variables in table 1.

  • †Favorable outcome defined as a 90-day mRS score of 0 to 2.

  • ‡Defined as a 90-day mRS score of 0 to 1.

  • §Defined as a mTICI 2b/3.

  • ¶Defined as a mTICI 3.

  • ASPECTS, Alberta Stroke Program Early CT Score; IPTW, inverse probability of treatment weighting; IVT, intravenous thrombolysis; mRS, modified Rankin Scale; mTICI, modified Thrombolysis in Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale; PH2, parenchymal hemorrhage type 2; sICH, symptomatic intracerebral hemorrhage.