Comparisons of clinical and procedural outcomes according to intravenous thrombolysis use in patients treated with carotid artery stenting (secondary analysis) before and after inverse probability of treatment weighting
| Outcomes | IVT− (n=126) | IVT+ (n=214) | Before IPTW | After IPTW | ||
| Effect size (95% CI) | P value | Effect size (95% CI) | P value | |||
| Clinical outcomes | ||||||
| Favorable outcome* | 62 (49.2) | 130 (60.7) | 1.59 (1.01 to 2.50) | 0.043 | 1.11 (1.01 to 1.24) | 0.049 |
| Excellent outcome† | 42 (33.3) | 94 (43.9) | 1.58 (0.99 to 2.51) | 0.054 | 1.09 (0.98 to 1.21) | 0.10 |
| 90-Day mortality | 24 (19.0) | 16 (7.5) | 0.35 (0.17 to 0.69) | 0.002 | 0.90 (0.84 to 0.97) | 0.005 |
| Hemorrhagic complications | ||||||
| sICH | 11 (8.7) | 16 (7.5) | 0.83 (0.37 to 1.85) | 0.64 | 0.98 (0.92 to 1.04) | 0.47 |
| PH2 | 10 (7.9) | 12 (5.6) | 0.66 (0.27 to 1.59) | 0.35 | 0.96 (0.91 to 1.02) | 0.16 |
| 24-Hour NIHSS score shift, median (IQR) | 0.0 (−5.0−2.0) | −4.0 (−9.0−0.0) | −3.2 (−5.9 to −0.5) | 0.022 | −3.0 (−5.6 to −0.3) | 0.030 |
| 24-Hour ASPECTS shift, median (IQR) | −2.0 (−4.0−0.0) | −1.0 (−3.0−0.0) | 0.5 (−0.05 to 1.0) | 0.072 | 0.6 (0.07 to 1.2) | 0.026 |
| Procedural outcomes | ||||||
| Successful reperfusion‡ | 102 (81.0) | 182 (85.0) | 1.34 (0.75 to 2.40) | 0.33 | 1.05 (0.97 to 1.14) | 0.22 |
| Excellent reperfusion§ | 38 (30.2) | 72 (33.6) | 1.15 (0.72 to 1.84) | 0.55 | 1.04 (0.94 to 1.15) | 0.48 |
| Procedural complication | 12 (9.5) | 25 (11.7) | 1.26 (0.61 to 2.61) | 0.53 | 1.03 (0.96 to 1.10) | 0.45 |
Values are expressed as number (%) unless otherwise indicated.
Propensity score was calculated taking into account all variables in table 1 except carotid artery stenting factor.
*Favorable outcome defined as a 90-day mRS score of 0 to 2.
†Defined as a 90-day mRS score of 0 to 1.
‡Defined as a mTICI 2b/3.
§Defined as a mTICI 3. Descriptive parameters and effect sizes (odds ratio or mean difference) were calculated after multiple imputation to handle missing values for variables included in the propensity score.
ASPECTS, Alberta Stroke Program Early CT Score; IPTW, inverse probability of treatment weighting; IVT, intravenous thrombolysis; mRS, modified Rankin Scale; mTICI, modified Thrombolysis in Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale; PH2, parenchymal hemorrhage type 2; sICH, symptomatic intracerebral hemorrhage.