Table 1

Fictional case scenarios used in this study

Scenario	Occlusion site	Age	Sex	NIHSS	Onset to CT time	ASPECTS	CTP imaging findings	Intravenous alteplase
1A	M2/3	86	Male	9	130 min	9	CTP core volume (rCBF <30%) 7 mL CTP penumbra volume: not provided	Yes
1B	M2/3	86	Male	9	130 min	10	CTP core volume (rCBF <30%) 7 mL CTP penumbra volume: not provided	Not eligible
2A	A3	79	Male	8	135 min	NA	CTP core volume (rCBF <30%) 9 mL CTP penumbra volume (Tmax >6 s) 30 mL	Yes
2B	A3	79	Male	8	135 min	NA	CTP core volume (rCBF <30%) 7 mL CTP penumbra volume (Tmax >6 s) 30 mL	Not eligible
3A	P2/3	52	Male	8	90 min	NA	CTP core volume (rCBF <30%) 4 mL CTP penumbra volume (Tmax >6 s) 24 mL	Yes
3B	P2/3	52	Male	8	90 min	NA	CTP core volume (rCBF <30%) 4 mL CTP penumbra volume (Tmax >6 s) 24 mL	Not eligible

*A3, third segment of the anterior cerebral artery; ASPECTS, Alberta Stroke Program Early CT Score for early ischemic changes on CT; CTP, CT perfusion; M2/3, second/third segment of the middle cerebral artery; NA, not applicable (ASPECTS only accounts for middle cerebral artery territory); P2/3, second/third segment of the posterior cerebral artery; rCBF, relative cerebral blood flow.