Table 1

Patient characteristics

CharacteristicsMS (n=221)DS (n=314)P value
Age (years) (median (IQR))77 (66–83)77 (66–82)0.912
Males (n (%))104 (47)137 (42)0.433
Medical history (n (%))
 Hypertension179 (81)259 (82)0.659
 Diabetes mellitus53 (24)61 (19)0.205
 Hyperlipidemia72 (33)91 (29)0.373
 Atrial fibrillation69 (31)131 (42)0.014
 Smoking history79 (36)96 (31)0.209
Baseline medication (n (%))
 Antithrombotic medication110 (50)161 (51)0.733
 Antihypertensive drugs156 (71)227 (72)0.667
Clinical presentation
 Unknown time of symptom onset (n (%))38 (17)33 (11)0.025
 NIHSS at CSC presentation (median (IQR))16 (11–20)14 (10–14)0.016
 Systolic blood pressure mm Hg) (median (IQR))158 (137–179)160 (144–225)0.125
 Diastolic blood pressure (mm Hg) (median (IQR))80 (70–95)85 (72–99)0.35
 Heart rate (beats/min) (median (IQR))78 (67–90)79 (67–90)0.982
Treatment
 IV alteplase (n (%))109 (49)164 (52)0.508
Intervention (n (%))
 No MT after interfacility transfer60 (19)
 Recanalization after remote IV alteplase10 (3)
 No large vessel occlusion after transfer5 (2)
 Far distal occlusion not suitable for MT6 (2)
 Far advanced infarct progression not suitable for MT34 (11)
 No consent for treatment2 (1)
 No endovascular access route to the occlusion location3 (1)
Onset to puncture (min) (median (IQR))136 (110–164)266 (230–326)<0.0001
Occlusion location (n (%))*
 M1131 (59)195 (62)0.509
 M233 (15)60 (19)0.209
 ICA90 (41)121 (39)0.61
Stent retrieval maneuvers (median (IQR))2 (1–3)2 (1–3)0.779
Successful recanalization (mTICI ≥2 b) (n (%))181 (82)219 (87)0.001
Duration of MT procedure (min) (median (IQR))70 (45–111)75 (49–99)0.947
Onset to recanalization (min) (median (IQR))210 (168–271)346 (296–416)<0.0001
Cervical ICA stenting (n (%))36 (16)52 (17)0.934
Clinical outcome
 NIHSS score 24 hours postintervention (median (IQR))6 (1–15)5 (2–13)0.854
 Intracranial hemorrhage (n (%))35 (16)42 (13)0.425
 Inhouse mortality (n (%))41 (19)51 (16)0.486
  • Values are number (%) for categorial variables and median (IQR) for continuous variables.

  • *Including combined vessel occlusions.

  • CSC, comprehensive stroke center; DS, drip and ship; ICA, internal carotid artery; IV, intravenous; M1/M2, middle cerebral artery segment; MS, mothership; MT, mechanical thrombectomy; mTICI, modified Treatment in Cerebral Ischemia Scale; NIHSS, National Institutes of Health Stroke Scale.