Large published studies related to the anesthetic management of patients with acute ischemic stroke
| Study | Summary of results |
| North American Solitaire Acute Stent Retriever Registry8 | GA associated with increased mortality and lower odds of functional outcome |
| John et al3 | GA associated with parenchymal hematoma |
| Brinjikji et al19 | Meta-analysis of 22 studies that showed higher odds of death, respiratory complications, and lower odds of functional outcomes after GA |
| Bekelis et al9 | GA was associated with increased mortality and length of stay |
| DEFUSE 3 trial10 | GA was associated with lower functional independence at 90 days and higher NIHSS score after 24 hours |
| Feil et al13 | GA was associated with worse clinical outcomes at 24 hours, at discharge, and at follow-up at 3 months |
| Goyal et al20 | A meta-analysis of 16 studies showed lower functional independence and higher odds of 3 month mortality with GA. |
| Cappellari et al12 | A cohort study from the Italian Registry that showed GA was associated with worse 3 month functional outcomes |
| Farag et al42 | GA was associated with higher mortality rate compared with MAC |
| SIESTA ANSTROKE GOLIATH15–17 | Functional outcome was not different between GA vs MAC, but there was potential positive signal in favor of GA |
| Schonenberger et al21 | In a meta-analysis of RCTs, the use of GA was associated with less disability at 3 months |
| Simonsen et al22 | In this meta-analysis, the use of GA was associated with better outcomes than MAC |
| Maurice et al18 | This RCT of 345 patients showed no difference in the functional outcomes 3 months after EVT between GA vs MAC |
GA, general anesthesia; MAC, monitored anesthesia care; NIHSS, National Institutes of Health Stroke Scale; RCT, randomized controlled trial.