Cohort demographic characteristics, medical history, and clinical data before and after propensity score matched analysis.
| Variable | Unmatched cohort | P value | Propensity score matched cohort | P value | ||||
| Age ≥90 years (n=26) | Age <90 years (n=188) | d* | Age ≥90 years (n=23) | Age <90 years (n=66) | d* | |||
| Patient demographics and comorbidities | ||||||||
| Sex (female) | 21 (80.8) | 100 (53.2) | 61.3 | 0.01 | 18 (78.3) | 47 (71.2) | 16.3 | 0.59 |
| Atrial fibrillation | 12 (46.2) | 69 (36.7) | 19.3 | 0.35 | 9 (39.1) | 29 (43.9) | −9.8 | 0.69 |
| Coronary artery disease | 9 (34.6) | 62 (33.0) | 3.5 | 0.87 | 7 (30.4) | 25 (37.9) | −15.7 | 0.52 |
| Chronic kidney disease | 8 (30.8) | 38 (20.2) | 24.4 | 0.22 | 6 (26.1) | 19 (28.8) | −6.1 | 0.80 |
| Diabetes | 3 (11.5) | 52 (27.7) | −41.5 | 0.10 | 3 (13.0) | 16 (24.2) | −29.1 | 0.38 |
| Heart valve disease | 2 (7.7) | 10 (5.3) | 9.6 | 0.64 | 1 (4.3) | 3 (4.5) | −1.0 | 1.00 |
| Hyperlipidemia | 12 (46.2) | 89 (47.3) | −2.4 | 0.91 | 10 (43.5) | 33 (50.0) | −13.1 | 0.59 |
| Hypertension | 22 (84.6) | 145 (77.1) | 19.1 | 0.46 | 19 (82.6) | 56 (84.8) | −6.1 | 0.75 |
| Mechanical heart valve | 0 (0) | 10 (5.3) | −33.5 | 0.61 | 0 (0) | 0 (0) | – | 1.00 |
| Previous myocardial infarction | 2 (7.7) | 11 (5.9) | 7.3 | 0.66 | 1 (4.3) | 3 (4.5) | −1.0 | 1.00 |
| Smoker (current) | 0 (0) | 36 (19.1) | −68.8 | 0.01 | 0 (0) | 0 (0) | – | 1.00 |
| Patient characteristics | ||||||||
| NIHSS | 14 (10–20) | 16 (11–19) | −4.6 | 0.42 | 14 (10–18) | 14 (10–19) | −7.4 | 0.76 |
| Transferred from spoke hospital | 10 (38.5) | 67 (35.6) | 5.8 | 0.78 | 8 (34.8) | 25 (37.9) | −6.4 | 0.79 |
| IV alteplase prior to EVT | 9 (34.6) | 47 (25.0) | 21.1 | 0.31 | 8 (34.8) | 22 (33.3) | 3.1 | 0.90 |
| Location and volume | ||||||||
| Hemisphere of LVO (left) | 11 (42.3) | 102 (54.3) | 0.25 | 9 (39.1) | 31 (47.0) | 0.52 | ||
| Vessel of LVO | 0.61 | 0.69 | ||||||
| ICA | 5 (19.2) | 38 (20.2) | 5 (21.7) | 9 (13.6) | ||||
| Tandem | 0 (0.0) | 9 (4.8) | 0 (0.0) | 2 (3.0) | ||||
| M1 | 14 (53.8) | 104 (55.3) | 13 (56.5) | 40 (60.6) | ||||
| M2 | 7 (26.9) | 37 (19.7) | 5 (21.7) | 15 (22.7) | ||||
| Ischemic core (mL)† | 2.5 (0–14) | 7 (0–23) | −25.4 | 0.25 | 6 (0–24) | 0 (0–12) | 14.3 | 0.44 |
| Mismatch volume | 72 (45–102) | 71 (45–110) | −2.7 | 0.93 | 71 (42–81) | 66 (45–105) | −2.4 | 0.91 |
| Procedure | ||||||||
| Door to groin puncture | 85 (34–132) | 81 (52–109) | 23.5 | 0.49 | 87 (37–128) | 84 (48–116) | 20.5 | 0.46 |
| Recanalization after first pass | 18 (69.2) | 105 (55.9) | 27.9 | 0.20 | 15 (65.2) | 38 (57.6) | 15.7 | 0.52 |
| Complications | 1 (3.8) | 2 (1.6) | 0.32 | 1 (4.3) | 1 (1.5) | 0.45 | ||
| Failed EVT‡ | 0 (0.0) | 9 (4.8) | 0.60 | 0 (0.0) | 3 (4.5) | 0.57 | ||
All values are n (%) or median (IQR).
Proportion P values assessed by chi square or Fisher’s exact test as appropriate. Nonparametric measures assessed by Mann–Whitney test.
*Standardized difference.
†Defined as volume of blood flow <30% by computed tomography perfusion imaging.
‡Defined as Thrombolysis in Cerebral Infarction (TICI) score of 0.
EVT, endovascular thrombectomy; ICA, internal carotid artery; IQR, interquartile range; IV, intravenous; LVO, large vessel occlusion; MI, myocardial infarction; NIHSS, National Institutes of Health Stroke Scale.