Table 1

Subgroup analysis of published randomized controlled trials

StudySourceOutcomeSubgroupacOR/aOR point estimate (95% CI)
MRCLEAN-NoIV5online supplemental figure S3Ordinal mRS scoreOTR 13–77 min
OTR 77–124 min
OTR 124–734
0.75 (0.43 to 1.31)
0.67 (0.39 to 1.15)
1.00 (0.58 to 1.73)
DIRECT-MT18online supplemental figure S4Ordinal mRS scoreOTR ≤125 min
OTR 126–171 min
OTR 172–210 min
OTR >210 min
0.93 (0.54 to 1.61)
0.94 (0.54 to 1.64)
1.28 (0.74 to 2.22)
1.38 (0.79 to 2.40)
DEVT19online supplemental eFigure 6mRS 0–2OTR <169 min
OTR ≥169 min
0.97 (0.41 to 2.3)
2.25 (0.88 to 6.05)
SKIP6Main paper figure 3mRS 0–2OTR <120 min
OTR ≥120 min
0.77 (0.33 to 1.78)
1.33 (0.61 to 2.87)
  • In all trials a higher aOR/acOR favors withholding bridging IVT, while a lower aOR/acOR favors administering IVT before MT.

  • acOR, adjusted common OR; aOR, adjusted OR; IVT, intravenous thrombolysis; mRS, modified Rankin Scale; OTR, onset-to-randomization time.