Table 3

Interaction analysis regarding primary and secondary outcomes according to overall and in-hospital delays

TimeOutcome categoryOutcomeaOR for MT alone per 1 hour delay with 95% CIaOR of interaction per 1 hour delay with 95% CI*
Onset-to-needle* time:
Expected time from symptom onset or last known well to IVT bolus
EfficacymRS 0–2 (primary), day 900.86, 0.60 to 1.230.76, 0.45 to 1.30
mRS decrease (better outcome), day 900.82, 0.60 to 1.120.90, 0.58 to 1.39
Mortality, day 901.57, 0.91 to 2.700.98, 0.42 to 2.32
SafetyAny ICH on 24 hours imaging1.35, 0.93 to 1.971.33, 0.78 to 2.27
Symptomatic ICH on 24 hours imaging1.15, 0.42 to 3.170.66, 0.17 to 2.65
Pharmacological efficacyPre-interventional reperfusion success
(cs-eTICI ≥2a)
0.99, 0.40 to 2.421.56, 0.54 to 4.49
Time-to-reperfusion0.73, 0.60 to 0.891.24, 0.94 to 1.62,
Final reperfusion success (cs-eTICI ≥2b)0.78, 0.44 to 1.371.04, 0.36 to 3.02
Door-to-needle* time:
Expected time from arrival at the emergency department door to IVT bolus
EfficacymRS 0–2 (primary), day 901.47, 0.60 to 3.560.48, 0.14 to 1.62
mRS decrease (better outcome), day 901.88, 0.91 to 3.880.36, 0.13 to 0.99
Mortality, day 900.11, 0.02 to 0.6617.8, 1.8 to 174.9
SafetyAny ICH on 24 hours imaging0.99, 0.40 to 2.430.95, 0.28 to 3.24
Symptomatic ICH on 24 hours imaging0.73, 0.05 to 10.744.60, 0.19 to 114.10
Pharmacological efficacyPre-interventional reperfusion success
(cs-eTICI ≥2a)
2.26, 0.36 to 14.380.63, 0.07 to 6.06
Time-to-reperfusion0.40, 0.26 to 0.630.88, 0.47 to 1.64
Final reperfusion success (cs-eTICI ≥2b)1.69, 0.37 to 7.810.56, 0.05 to 6.83
  • *The aOR indicates the interaction term of assignment to IVT+MT (as compared with MT alone) and 1 hour delay and group assignment assuming a linear effect. The OR for MT alone gives the change in the odds for functional independence per additional hour delay. The interaction refers to change in the treatment effect (odds for functional independence of IVT plus MT vs MT alone) per additional hour delay.

  • aOR, adjusted OR; cs-eTICI, cross-sectional expanded Thrombolysis In Cerebral Infarction; ICH, intracranial hemorrhage; IVT, intravenous thrombolysis; mRS, modified Rankin Scale; MT, mechanical thrombectomy.