Baseline characteristics of the study population, stratified by ICH occurrence and concomitant neurological deterioration
| Characteristics | No ICH (n=596) | Asymptomatic ICH (n=331) | Symptomatic ICH (n=90) | Missing |
| Age, years; median (IQR) | 71 (62–79) | 72 (63–80) | 75 (66–83) | 0 |
| Men, n (%) | 325 (55) | 193 (58) | 44 (49) | 0 |
| Trial, n (%) | 0 | |||
| MR CLEAN-NO IV | 300 (50) | 145 (44) | 25 (28) | |
| MR CLEAN-MED | 296 (50) | 186 (56) | 65 (72) | |
| Pre-stroke mRS score, n (%) | 2 | |||
| 0 | 419 (70) | 230 (70) | 51 (57) | |
| 1 | 107 (18) | 56 (17) | 22 (24) | |
| 2 | 54 (9.1) | 33 (10) | 10 (11) | |
| ≥3 | 15 (3.0) | 11 (3.3) | 7 (7.8) | |
| Medical history | ||||
| Atrial fibrillation, n (%) | 101 (17) | 63 (19) | 21 (23) | 0 |
| Diabetes mellitus, n (%) | 80 (13) | 59 (18) | 19 (21) | 0 |
| Myocardial infarction, n (%) | 72 (12) | 29 (8.8) | 13 (14) | 0 |
| Prior antithrombotic drug use | ||||
| Antiplatelet, n (%) | 184 (31) | 109 (33) | 41 (46) | 0 |
| Coumarine, n (%)" | 40 (6.7) | 23 (6.9) | 10 (11) | 0 |
| Direct oral anticoagulant, n (%) | 36 (6.0) | 21 (6.3) | 6 (6.7) | 0 |
| Heparin, n (%) | 4 (0.7) | 1 (0.3) | 1 (1.1) | 0 |
| SBP at baseline, mm Hg; mean (SD) | 150 (25) | 151 (25) | 156 (24) | 7 |
| NIHSS score at baseline; median (IQR) | 15 (8–19) | 16 (11–20) | 17 (10–21) | 18 |
| ASPECTS at baseline NCCT; median (IQR) | 9 (8–10) | 9 (7–10) | 9 (8–10) | 3 |
| Level of occlusion on CTA, n (%) | 3 | |||
| ICA or ICA-T | 148 (25) | 84 (25) | 20 (22) | |
| M1 | 331 (56) | 183 (55) | 43 (48) | |
| M2 | 112 (19) | 63 (19) | 26 (29) | |
| None | 2 (0.3) | 1 (0.3) | 1 (1.1) | |
| Treatment with intravenous thrombolytics, n (%) | 374 (63) | 204 (62) | 64 (71) | 0 |
| Onset to groin puncture time, median (IQR) | 150 (115–195) | 161 (130–218) | 194 (145–254) | 20 |
| Periprocedural treatment with aspirin, n (%) | 128 (21) | 91 (27) | 46 (51) | 1 |
| Periprocedural treatment with heparin, n (%) | 193 (32) | 126 (38) | 47 (52) | 2 |
| Post-EVT eTICI score, n (%) | 56 | |||
| 0 | 46 (8.3) | 26 (8.2) | 6 (6.7) | |
| 1 | 11 (2.0) | 5 (1.6) | 0 (0.0) | |
| 2a | 43 (7.8) | 32 (10) | 9 (10) | |
| 2b | 107 (19) | 85 (27) | 22 (24) | |
| 2c | 71 (13) | 39 (12) | 11 (12) | |
| 3 | 275 (50) | 132 (41) | 41 (46) | |
Continuous variables are presented as median and IQR or mean and SD. Categorical variables are presented as frequencies (n) and percentages (%).
ASPECTS, Alberta Stroke Program Early CT Score; CTA, CT angiography; eTICI, extended thrombolysis in cerebral infarction; EVT, endovascular treatment; ICA(-T), internal carotid artery (terminus); ICH, intracranial hemorrhage; mRS, modified Rankin Scale; mRS, modified Rankin Scale; NCCT, non-contrast CT; NIHSS, National Institutes of Health Stroke Scale; SBP, systolic blood pressure.