Table 1

Baseline characteristics of the study population, stratified by ICH occurrence and concomitant neurological deterioration

CharacteristicsNo ICH
(n=596)
Asymptomatic ICH
(n=331)
Symptomatic ICH
(n=90)
Missing
Age, years; median (IQR)71 (62–79)72 (63–80)75 (66–83)0
Men, n (%)325 (55)193 (58)44 (49)0
Trial, n (%)0
MR CLEAN-NO IV300 (50)145 (44)25 (28)
MR CLEAN-MED296 (50)186 (56)65 (72)
Pre-stroke mRS score, n (%)2
0419 (70)230 (70)51 (57)
1107 (18)56 (17)22 (24)
254 (9.1)33 (10)10 (11)
≥315 (3.0)11 (3.3)7 (7.8)
Medical history
Atrial fibrillation, n (%)101 (17)63 (19)21 (23)0
Diabetes mellitus, n (%)80 (13)59 (18)19 (21)0
Myocardial infarction, n (%)72 (12)29 (8.8)13 (14)0
Prior antithrombotic drug use
Antiplatelet, n (%)184 (31)109 (33)41 (46)0
Coumarine, n (%)"40 (6.7)23 (6.9)10 (11)0
Direct oral anticoagulant, n (%)36 (6.0)21 (6.3)6 (6.7)0
Heparin, n (%)4 (0.7)1 (0.3)1 (1.1)0
SBP at baseline, mm Hg; mean (SD)150 (25)151 (25)156 (24)7
NIHSS score at baseline; median (IQR)15 (8–19)16 (11–20)17 (10–21)18
ASPECTS at baseline NCCT; median (IQR)9 (8–10)9 (7–10)9 (8–10)3
Level of occlusion on CTA, n (%)3
ICA or ICA-T148 (25)84 (25)20 (22)
M1331 (56)183 (55)43 (48)
M2112 (19)63 (19)26 (29)
None2 (0.3)1 (0.3)1 (1.1)
Treatment with intravenous thrombolytics, n (%)374 (63)204 (62)64 (71)0
Onset to groin puncture time, median (IQR)150 (115–195)161 (130–218)194 (145–254)20
Periprocedural treatment with aspirin, n (%)128 (21)91 (27)46 (51)1
Periprocedural treatment with heparin, n (%)193 (32)126 (38)47 (52)2
Post-EVT eTICI score, n (%)56
046 (8.3)26 (8.2)6 (6.7)
111 (2.0)5 (1.6)0 (0.0)
2a43 (7.8)32 (10)9 (10)
2b107 (19)85 (27)22 (24)
2c71 (13)39 (12)11 (12)
3275 (50)132 (41)41 (46)
  • Continuous variables are presented as median and IQR or mean and SD. Categorical variables are presented as frequencies (n) and percentages (%).

  • ASPECTS, Alberta Stroke Program Early CT Score; CTA, CT angiography; eTICI, extended thrombolysis in cerebral infarction; EVT, endovascular treatment; ICA(-T), internal carotid artery (terminus); ICH, intracranial hemorrhage; mRS, modified Rankin Scale; mRS, modified Rankin Scale; NCCT, non-contrast CT; NIHSS, National Institutes of Health Stroke Scale; SBP, systolic blood pressure.