Table 2

Regression analyses of the association of any intracranial hemorrhage (model 1), intracranial hemorrhage classified according to symptoms (model 2), and intracranial hemorrhage classified according to the Heidelberg Bleeding Classification (model 3) with the modified Rankin Scale score at 90 days

Common OR
(95% CI)		Adjusted common odds ratio (95% CI)*
Model 1
 Any intracranial hemorrhage0.31 (0.25 to 0.39)0.59 (0.46 to 0.76)
Model 2
 Asymptomatic intracranial hemorrhage0.44 (0.35 to 0.57)0.76 (0.58 to 0.98)
 Symptomatic intracranial hemorrhage0.04 (0.02 to 0.07)0.07 (0.04 to 0.14)
Model 3
 Isolated hemorrhagic infarction type 10.61 (0.42 to 0.89)0.76 (0.51 to 1.13)
 Isolated hemorrhagic infarction type 20.54 (0.36 to 0.82)1.00 (0.64 to 1.56)
 Isolated parenchymal hematoma type 10.32 (0.17 to 0.59)0.67 (0.35 to 1.30)
 Isolated parenchymal hematoma type 20.12 (0.06 to 0.27)0.37 (0.14 to 0.95)
 Isolated subarachnoid hemorrhage0.44 (0.25 to 0.77)0.55 (0.30 to 1.03)
 Other isolated hemorrhage (SDH/IVH/rPH)0.35 (0.12 to 1.01)0.50 (0.17 to 1.49)
 Combined hemorrhagic infarction with hemorrhage outside infarcted brain tissue0.23 (0.13 to 0.42)0.52 (0.27 to 1.03)
 Combined parenchymal hematoma with hemorrhage outside infarcted brain tissue0.06 (0.04 to 0.10)0.17 (0.10 to 0.30)
 Combined hemorrhages outside infarcted brain tissue0.20 (0.04 to 1.02)0.14 (0.03 to 0.74)

  • Effect estimates are presented as common odds ratios (OR) and adjusted common odds ratios (aOR) with 95% confidence intervals (CI). The reference for all models was ‘no intracranial hemorrhage’.

  • *Adjusted for age, sex, pre-stroke mRS score, history of hypertension, history of diabetes mellitus, history of myocardial infarction, prior use of antithrombotics, baseline NIHSS score, door intervention center to groin puncture time, intravenous thrombolytics, post-EVT eTICI score, final infarct volume, periprocedural treatment with aspirin, and periprocedural treatment with unfractionated heparin.

  • eTICI, extended thrombolysis in cerebral infarction; EVT, endovascular treatment; IVH, intraventricular hemorrhage; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; rPH, remote parenchymal hematoma; SDH, subdural hematoma.