Factors associated with thrombus migration
| Parameter | All patients (n=478) | Patients with KOS (n=257) | Patients with IVT (n=232) | Patients with IVT and KOS (n=169) | ||||
| aOR (95% CI) | P | aOR (95% CI) | P | aOR (95% CI) | P | aOR (95% CI) | P | |
| IVT | 4.07 (2.17 to 7.65) | <0.001 | 4.41 (1.74 to 11.15) | <0.01 | – | – | ||
| Ln‡ (time between sequential imaging)* | 2.37 (1.47 to 3.84) | <0.001 | 2.36 (1.31 to 4.23) | <0.001 | – | – | ||
| Needle-to-groin time >60 min | – | – | – | – | 2.60 (1.20 to 5.99) | 0.02 | ||
| Needle-to-groin time (tertiles) | – | – | Adjusted P for trend | 0.03 | ||||
| Tertile 3 vs Tertile 1 4.03 (1.40 to 11.58) | 0.01 | |||||||
| Tertile 2 vs Tertile 1 2.86 (0.98 to 8.34) | 0.05 | |||||||
| Distal location of LVO† | 1.68 (0.96 to 2.95) | 0.07 | 1.96 (0.99 to 3.89) | 0.07 | 2.14 (1.10 to 4.15) | 0.03 | 2.69 (1.23 to 5.85) | 0.01 |
| LAA etiology | 0.53 (0.28 to 1.00) | 0.051 | 0.50 (0.28 to 1.00) | 0.053 | 0.54 (0.28 to 1.13) | 0.10 | 0.45 (0.19 to 1.10) | 0.08 |
Numbers in bold type denote statistical significance.
*Imaging-to-groin or imaging-to-imaging time.
†Distal segment of MCA M1 and MCA M2/3/4 segments vs ICA and proximal segment of MCA M1.
‡natural logarithm
.aOR, adjusted odds ratio; CI, confidence interval; ICA, internal carotid artery; IVT, intravenous thrombolysis; KOS, known onset of stroke; LAA, large artery atherosclerosis; LVO, large vessel occlusion; MCA, middle cerebral artery.