Table 4

Main study results

	MSIG (n=12)	CG1 (n-10)	P value	CG2 (n=25)	P value
NIHSS score at admission; median (IQR)	14.0 (5–22)	15.5 (5–24)	0.888*	16.0 (4–22)	0.757*
NIHSS score after 24 hours; median (IQR)	7.0 (0–21)	16.0 (2–23)	0.241*	14.0 (3–25)	0.158*
NIHSS at day 7 (alive only); median (IQR)	3.0 (0–19)	13 (2–19)	0.502*	14 (2–35)	0.110*
mRS score 0–2 prior to stroke; n (%)	12 (100.0)	9 (90.0)	0.910†	25 (100.0)	1.000
mRS score 3 prior to stroke; n (%)	0 (0.0)	1 (10.0)	0.910†	0 (0.0)	1.000
mRS score 0–1 at day 90; n (%)	6 (50.0)	1 (10.0)	0.148†	2 (8.0)	0.016†
mRS score 0–2 at day 90; n (%)	7 (58.3)	1 (10.0)	0.062†	3 (12.0)	0.012†
mRS score 0–3 at day 90; n (%)	7 (58.3)	2 (20.0)	0.198†	4 (16.0)	0.036†
mRS score 4–5 at day 90; n (%)	1 (8.3)	2 (20.0)	0.667†	15 (60.0)	0.003†
Death within 7 days; n (%)	0 (0.0)	3 (30.0)	0.156†	0 (0.0)	1.000
Death within 90 days; n (%)	4 (33.3)	6 (60.0)	0.782†	6 (24.0)	1.000†
Cerebral edema; n (%)	0 (0.0)	3 (30.0)	0.156†	4 (16.0)	0.564†
Decompressive craniectomy; n (%)	0 (0.0)	0 (0.0)	1.000†	1 (4.0)	1.000†
sICH; n (%)	0 (0.0)	0 (0.0)	1.000†	1 (4.0)	1.000†

*Mann-Whitney U-test;
†Fisher’s exact test;
CG1, control group in center 1; CG2, control group in center 2; mRS, modified Rankin scale; MSIG, microsurgical intervention group; NIHSS, National Institutes of Health Stroke Scale; sICH, symptomatic intracerebral hemorrhage.