Baseline characteristics of the three occlusion pattern groups
| Baseline characteristics | Main stem (n=370) | Single branch (n=151) | Double branch (n=502) | P value |
| Age – median (IQR) | 70 (59–79) | 74 (62–82) | 73 (63–80) | 0.03 |
| Sex, female – no./total (%) | 174/370 (47) | 73/151 (48) | 255/502 (51) | 0.54 |
| Medical history – no./total (%) | ||||
| Previous stroke | 60/368 (16) | 27/149 (18) | 93/500 (19) | 0.67 |
| Diabetes mellitus | 63/369 (17) | 18/150 (12) | 87/500 (17) | 0.27 |
| Hypertension | 185/364 (51) | 83/147 (56) | 274/495 (55) | 0.33 |
| Atrial fibrillation | 87/367 (24) | 37/147(25) | 132/499 (26) | 0.66 |
| Pre-stroke mRS score – no./total (%) | 0.43 | |||
| 0 | 243/363 (67) | 91/147 (62) | 327/491 (67) | |
| 1 | 57/363 (16) | 25/147 (17) | 63/491 (13) | |
| 2 | 26/363 (7) | 8/147 (5) | 35/491 (7) | |
| ≥3 | 37/363 (10) | 23/147 (16) | 66/491 (13) | |
| Systolic blood pressure† (mm Hg) – median (IQR) | 150 (130–166) | 149 (130–165) | 146 (130–162) | 0.77 |
| Diastolic blood pressure‡ (mm Hg) – median (IQR) | 80 (71–91) | 80 (70–90) | 80 (70–90) | 0.44 |
| NIHSSBL§ – median (IQR) | 15 (11–18) | 16 (12–20) | 15 (11–19) | 0.11 |
| ASPECTSBL¶ – median (IQR) | 9 (8–10) | 9 (8–10) | 9 (8–10) | 0.99 |
| CS – no./total (%) | <0.01 | |||
| 0 | 8/358 (2) | 0/150 (0) | 28/492 (6) | |
| 1 | 75/358 (21) | 56/150 (37) | 179/492 (36) | |
| 2 | 143/358 (40) | 80/150 (53) | 209/492 (42) | |
| 3 | 132/358 (37) | 14/150 (10) | 76/492 (15) | |
| CBS | 8 (6–8) | 7 (5–7) | 6 (4–6) | <0.01 |
| Treatment and workflow | ||||
| IVT – no./total (%) | 277/370 (75) | 112/151 (74) | 365/502 (73) | 0.66 |
| Transferred patients – no./total (%) | 191/370 (52) | 89/151 (59) | 281/502 (56) | 0.24 |
| Stroke onset* to first hospital presentation** (min) – median (IQR) | 55 (38–104) | 57 (40–105) | 57 (40–101) | 0.72 |
| Hospital presentation to IVT†† (min) – median (IQR) | 25 (19–32) | 23 (17–33) | 24 (18–33) | 0.41 |
| Stroke onset* to groin puncture (min) – median (IQR) | 193 (150–255) | 209 (160–270) | 192 (147–255) | 0.12 |
*Time of stroke onset was defined as the time of witnessed symptom onset or, if unknown, as the time the patient was last seen well.
†Missing value: 26.
‡Missing value: 31.
§Missing value: 13.
¶Missing value: 1.
**Missing value: 185.
††Missing value: 429
ASPECTS, Alberta Stroke Programme Early CT Score; BL, baseline; CBS, clot burden score; CS, collateral score; CT, computed tomography; IQR, interquartile range; IVT, intravenous treatment with alteplase; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale.