Baseline characteristics and procedural metrics in patients with excellent reperfusion (mTICI 2c-3)
| Good outcome (n=60) | Poor outcome (n=60) | All patients (n=120) | P value | Missing data/n (%) | |
| Age, mean (SD) | 64 (19) | 69 (13) | 67 (16) | 0.141 | 0/120 (0.0) |
| Female sex, n (%) | 24 (40.0) | 17 (28.3) | 41 (34.2) | 0.178 | 0/120 (0.0) |
| Hypertension, n (%) | 34 (56.7) | 38 (65.5) | 72 (61.0) | 0.324 | 2/120 (1.6) |
| Hypercholesterolemia, n (%) | 22 (36.7) | 26 (44.8) | 48 (40.7) | 0.367 | 2/120 (1.6) |
| Diabetes mellitus, n (%) | 11 (18.3) | 11 (19.0) | 22 (18.6) | 0.930 | 2/120 (1.6) |
| Smoking, n (%) | 14 (23.7) | 13 (23.2) | 27 (23.5) | 0.948 | 5/120 (4.1) |
| Previous antiplatelet treatment, n (%) | 10 (17.5) | 15 (25.4) | 25 (21.6) | 0.302 | 4/120 (3.3) |
| Previous oral anticoagulants, n (%) | 7 (12.3) | 8 (13.6) | 15 (12.9) | 0.837 | 4/120 (3.3) |
| Baseline systolic BP, mean (SD) | 151 (25) | 149 (30) | 150 (27) | 0.764 | 29/120 (24.1) |
| Baseline diastolic BP, mean (SD) | 85 (16) | 81 (15) | 83 (16) | 0.289 | 30/120 (25.0) |
| Baseline glycemia (mmol/L), mean (SD) | 8 (2) | 7 (3) | 7 (3) | 0.482 | 34/120 (28.3) |
| Pre-stroke mRS ≤2, n (%) | 6 (10.0) | 5 (8.3) | 11 (9.2) | 0.752 | 0/120 (0.0) |
| Initial NIHSS score, median (IQR) | 11 (12) | 23 (31) | 14 (20) | 0.000 | 5/120 (4.1) |
| Admission mode, n (%) | |||||
| Drip and ship | 33 (57.9) | 35 (59.3) | 68 (58.6) | 0.876 | 4/120 (3.3) |
| Mothership | 24 (42.1) | 24 (40.7) | 48 (41.4) | ||
| Initial imaging modality, n (%) | |||||
| CT | 10 (17.5) | 26 (44.1) | 36 (31.0) | 0.002 | 4/120 (3.3) |
| MRI | 47 (82.5) | 33 (55.9) | 80 (69.0) | ||
| pc-ASPECTS score, median (IQR) | 8 (2) | 7 (2) | 7 (3) | 0.013 | 16/120 (13.3) |
| Stroke etiology, n (%) | |||||
| TOAST 1 (atheroma) | 18 (62.1) | 13 (33.3) | 31 (45.6) | 0.043 | 52/120 (43.3) |
| TOAST 4 (dissection) | 2 (6.9) | 2 (5.1) | 4 (5.9) | ||
| TOAST 5 (unknown) | 9 (31.0) | 24 (61.5) | 33 (48.5) | ||
| Positive FLAIR MRI, n (%) | 18 (42.9) | 19 (61.3) | 37 (50.7) | 0.119 | 47/120 (39.1) |
| Intravenous thrombolysis, n (%) | 30 (50.0) | 15 (25.0) | 45 (37.5) | 0.005 | 0/120 (0.0) |
| First-line thrombectomy strategy, n (%) | |||||
| Contact aspiration | 40 (70.2) | 42 (71.2) | 82 (70.7) | 0.993 | 4/120 (3.3) |
| Stent retriever | 4 (7.0) | 4 (6.8) | 8 (6.9) | ||
| Combined | 13 (22.8) | 13 (22.0) | 26 (22.4) | ||
| Adjunctive treatment, n (%) | |||||
| None | 51 (86.4) | 50 (84.7) | 101 (85.6) | 0.835 | 2/120 (1.6) |
| Balloon angioplasty | 2 (3.4) | 2 (3.4) | 4 (3.4) | ||
| Intraprocedural antiplatelet treatment | 1 (1.7) | 2 (3.4) | 3 (2.5) | ||
| Antiplatelets and balloon angioplasty | 4 (6.8) | 5 (8.5) | 9 (7.6) | ||
| Stenting | 1 (1.7) | 0 (0.0) | 1 (0.8) | ||
| Number of passes, median (IQR) | 1 (0) | 1 (2) | 1 (1) | 0.003 | 4/120 (3.3) |
| Anesthesia type, n (%) | |||||
| General anesthesia | 23 (38.3) | 17 (28.3) | 40 (33.3) | 0.416 | 0/120 (0.0) |
| Conscious sedation | 34 (56.7) | 41 (68.3) | 75 (62.5) | ||
| Local anesthesia | 3 (5.0) | 2 (3.3) | 5 (4.2) | ||
| Onset to puncture (min), median (IQR) | 272 (134) | 284 (184) | 277 (156) | 0.215 | 0/120 (0.0) |
| Onset to imaging (min), median (IQR) | 128 (84) | 138 (76) | 131 (79) | 0.661 | 5/120 (4.1) |
| Imaging to puncture (min), median (IQR) | 115 (112) | 150 (126) | 137 (111) | 0.145 | 4/120 (3.3) |
| Puncture to reperfusion (min), median (IQR) | 35 (29) | 45 (46) | 40 (37) | 0.107 | 1/120 (0.8) |
| mTICI 3, n (%) | 54 (90.0) | 51 (85.0) | 105 (87.5) | 0.408 | 0/120 (0.0) |
| First pass mTICI 2b-3, n (%) | 47 (82.5) | 37 (62.7) | 84 (72.4) | 0.017 | 4/120 (3.3) |
| First pass mTICI 3, n (%) | 43 (75.4) | 28 (47.5) | 71 (61.2) | 0.002 | 4/120 (3.3) |
| Procedural complications, n (%) | 6 (10.0) | 6 (10.0) | 12 (10.0) | 1.000 | 0/120 (0.0) |
| Early neurological improvement, n (%) | 41 (68.3) | 19 (31.7) | 60 (50.0) | 0.000 | 0/120 (0.0) |
| Any hemorrhagic transformation, n (%) | 6 (10.9) | 21 (41.2) | 27 (25.5) | 0.000 | 14/120 (11.6) |
| PH hemorrhagic transformation, n (%) | 1 (1.8) | 8 (15.7) | 9 (8.5) | 0.010 | 14/120 (11.6) |
| Mortality at 90 days, n (%) | 0 (0.0) | 42 (71.2) | 42 (35.3) | 0.000 | 1/120 (0.8) |
BP, blood pressure; FLAIR, fluid attenuated inversion recovery ; mRS, modified Rankin Scale; mTICI, modified Thrombolysis In Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale; pc-ASPECTS, posterior circulation Alberta Stroke Programme Early CT Score ; PH, parenchymal hematoma.