Baseline characteristics and procedural metrics in patients with successful reperfusion (mTICI 2b-3)
| Good outcome (n=88) | Poor outcome (n=107) | All patients (n=195) | P value | Missing data/n (%) | |
| Age, mean (SD) | 62 (18) | 68 (13) | 65 (16) | 0.013 | 0/195 (0.0) |
| Female sex, n (%) | 39 (44.3) | 38 (35.5) | 77 (39.5) | 0.211 | 0/195 (0.0) |
| Hypertension, n (%) | 47 (53.4) | 69 (65.7) | 116 (60.1) | 0.082 | 2/195 (1.0) |
| Hypercholesterolemia, n (%) | 28 (31.8) | 50 (48.1) | 78 (40.6) | 0.022 | 3/195 (1.5) |
| Diabetes mellitus, n (%) | 13 (14.8) | 28 (26.7) | 41 (21.2) | 0.044 | 2/195 (1.0) |
| Smoking, n (%) | 21 (24.1) | 26 (26.8) | 47 (25.5) | 0.679 | 11/195 (5.6) |
| Previous antiplatelet treatment, n (%) | 14 (17.5) | 23 (25.0) | 37 (21.5) | 0.232 | 23/195 (11.7) |
| Previous oral anticoagulants, n (%) | 8 (10.0) | 12 (13.0) | 20 (11.6) | 0.535 | 23/195 (11.7) |
| Baseline systolic BP, mean (SD) | 149 (25) | 152 (31) | 150 (28) | 0.529 | 58/195 (29.7) |
| Baseline diastolic BP, mean (SD) | 84 (16) | 81 (16) | 82 (16) | 0.256 | 59/195 (30.2) |
| Baseline glycemia (mmol/L), mean (SD) | 8 (3) | 8 (3) | 8 (3) | 0.892 | 67/195 (34.3) |
| Pre-stroke mRS ≤2, n (%) | 12 (13.6) | 19 (17.8) | 31 (15.9) | 0.434 | 0/195 (0.0) |
| Initial NIHSS score, median (IQR) | 11 (12) | 25 (29) | 17 (22) | 0.000 | 8/195 (4.1) |
| Admission mode, n (%) | |||||
| Drip and ship | 49 (61.3) | 58 (63.0) | 107 (62.2) | 0.809 | 23/195 (11.7) |
| Mothership | 31 (38.8) | 34 (37.0) | 65 (37.8) | ||
| Initial imaging modality, n (%) | |||||
| CT | 16 (20.0) | 39 (42.4) | 55 (32.0) | 0.002 | 23/195 (11.7) |
| MRI | 64 (80.0) | 53 (57.6) | 117 (68.0) | ||
| pc-ASPECTS score, median (IQR) | 8 (2) | 7 (2) | 7 (3) | 0.001 | 23/195 (11.7) |
| Stroke etiology, n (%) | |||||
| TOAST 1 (atheroma) | 28 (56.0) | 37 (47.4) | 65 (50.8) | 0.647 | 67/195 (34.3) |
| TOAST 2 (cardioembolic) | 1 (2.0) | 3 (3.8) | 4 (3.1) | ||
| TOAST 4 (dissection) | 3 (6.0) | 3 (3.8) | 6 (4.7) | ||
| TOAST 5 (unknown) | 18 (36.0) | 35 (44.9) | 53 (41.4) | ||
| Positive FLAIR MRI, n (%) | 25 (43.1) | 32 (66.7) | 57 (53.8) | 0.015 | 89/195 (45.6) |
| Intravenous thrombolysis, n (%) | 48 (54.5) | 35 (32.7) | 83 (42.6) | 0.002 | 0/195 (0.0) |
| First-line thrombectomy strategy, n (%) | |||||
| Contact aspiration | 56 (68.3) | 71 (75.5) | 127 (72.2) | 0.538 | 19/195 (9.7) |
| Stent retriever | 9 (11.0) | 7 (7.4) | 16 (9.1) | ||
| Combined | 17 (20.7) | 16 (17.0) | 33 (18.8) | ||
| Adjunctive treatment, n (%) | |||||
| None | 74 (86.0) | 72 (71.3) | 146 (78.1) | 0.080 | 8/195 (4.1) |
| Balloon angioplasty | 2 (2.3) | 10 (9.9) | 12 (6.4) | ||
| Intraprocedural antiplatelet treatment | 1 (1.2) | 5 (5.0) | 6 (3.2) | ||
| Antiplatelets and balloon angioplasty | 6 (7.0) | 11 (10.9) | 17 (9.1) | ||
| Stenting | 3 (3.5) | 3 (3.0) | 6 (3.2) | ||
| Number of passes, median (IQR) | 1 (0) | 2 (2) | 1 (2) | 0.000 | 10/195 (5.1) |
| Anesthesia type, n (%) | |||||
| General anesthesia | 36 (40.9) | 36 (33.6) | 72 (36.9) | 0.573 | 0/195 (0.0) |
| Conscious sedation | 48 (54.5) | 66 (61.7) | 114 (58.5) | ||
| Local anesthesia | 4 (4.5) | 5 (4.7) | 9 (4.6) | ||
| Onset to puncture (min), median (IQR) | 268 (118) | 289 (166) | 270 (145) | 0.170 | 0/195 (0.0) |
| Onset to imaging (min), median (IQR) | 127 (77) | 145 (95) | 133 (90) | 0.397 | 24/195 (12.3) |
| Imaging to puncture (min), median (IQR) | 125 (96) | 146 (118) | 138 (107) | 0.163 | 23/195 (11.7) |
| Puncture to reperfusion (min), median (IQR) | 40 (37) | 48 (52) | 45 (46) | 0.042 | 1/195 (0.5) |
| mTICI 2c-3, n (%) | 60 (68.2) | 60 (56.1) | 120 (61.5) | 0.084 | 0/195 (0.0) |
| mTICI 3, n (%) | 54 (61.4) | 51 (47.7) | 105 (53.8) | 0.056 | 0/195 (0.0) |
| First pass mTICI 2b-3, n (%) | 65 (77.4) | 44 (44.9) | 109 (59.9) | 0.000 | 13/195 (6.6) |
| First pass mTICI 3, n (%) | 43 (50.6) | 28 (26.4) | 71 (37.2) | 0.001 | 4/195 (2.0) |
| Procedural complications, n (%) | 17 (19.3) | 13 (12.1) | 30 (15.4) | 0.167 | 0/195 (0.0) |
| Early neurological improvement, n (%) | 61 (69.3) | 45 (42.1) | 106 (54.4) | 0.000 | 0/195 (0.0) |
| Any hemorrhagic transformation, n (%) | 10 (12.3) | 32 (34.8) | 42 (24.3) | 0.001 | 22/195 (11.2) |
| PH hemorrhagic transformation, n (%) | 3 (3.8) | 11 (12.5) | 14 (8.3) | 0.040 | 27/195 (13.8) |
| Mortality at 90 days, n (%) | 0 (0.0) | 73 (69.5) | 73 (37.8) | 0.000 | 2/195 (1.0) |
BP, blood pressure; FLAIR, fluid attenuated inversion recovery; mRS, modified Rankin Scale; mTICI, modified Thrombolysis In Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale; pc-ASPECTS, posterior circulation Alberta Stroke Programme Early CT Score ; PH, parenchymal hematoma.