Table 2

Results of the univariable and multivariable logistic regression for MBE after endovascular thrombectomy in the training cohort

UnivariableMultivariable
MBENon-MBEP valueRegression coefficientOR (95% CI)P value
n=135n=508
Age, years, mean (SD)66 (12.1)67 (11.4)0.427
Men, n (%)81 (60.0)313 (61.6)0.732
Hypertension, n (%)106 (78.5)322 (63.4)0.0010.7042.022 (1.184 to 3.451)0.010
Diabetes, n (%)29 (21.5)82 (16.1)0.145
Atrial fibrillation, n (%)69 (51.1)228 (44.9)0.197
Baseline SBP, mm Hg, median (IQR)150 (133–165)149 (129–160)0.256
Baseline DBP, mm Hg, median (IQR)84 (72–92)81 (74–91)0.714
Baseline NIHSS score, median (IQR)18 (16–22)15 (12–19)<0.0010.0521.053 (1.010 to 1.099)0.015
Baseline ASPECT score, median (IQR)8 (5–9)9 (8–10)<0.001−0.2710.763 (0.682 to 0.852)<0.001
IVT, n (%)42 (31.1)107 (21.1)0.0140.6021.825 (1.095 to 3.042)0.021
TOAST classification, n (%)0.090
 Atherosclerotic36 (26.7)186 (36.6)
 Cardioembolic78 (57.8)259 (51.0)
 Others21 (15.6)63 (12.4)
OTP, min, median (IQR)279 (218–330)279 (219–359)0.697
OTR, min, median (IQR)380 (310–452)355 (285–445)0.127
Collateral status, n (%)<0.001
 Poor111 (82.2)240 (47.5)−1.106Reference
 Good24 (17.8)268 (52.8)0.331 (0.195 to 0.561)<0.001
First-line treatment, n (%)0.078
 Stent retriever89 (65.9)338 (66.7)
 Contact aspiration35 (25.9)98 (19.3)
 Angioplasty or stent11 (8.1)71(14)
mTICI 2b-3, n (%)87 (64.4)445 (87.6)<0.001−1.0950.334 (0.199 to 0.563)<0.001
Tandem, n (%)21 (15.6)85 (16.7)0.743
Occlusion site, n (%)<0.001
 MCA42 (31.1)314 (61.8)−0.9620.382 (0.241 to 0.606)<0.001
 ICA93 (68.9)194 (38.2)Reference
FBG, mmol/L, median (IQR)7.7 (6.0–10.1)6.0 (5.1–7.6)<0.0010.1171.124 (1.051 to 1.202)0.001
LDL, mmol/L, median (IQR)2.3 (1.8–2.9)2.3 (1.9–2.9)0.691
BUN, mmol/L, median (IQR)5.7 (4.6–8.0)5.6 (4.5–7.1)0.321
Cr, μmol/l, median (IQR)75.0 (63.0–99.5)74.0 (60.7–92.9)0.187
  • ASPECT, Alberta Stroke Program Early CT; BUN, blood urea nitrogen; Cr, creatinine; DBP, diastolic blood pressure; FBG, fasting blood glucose; ICA, internal carotid artery; IVT, intravenous thrombolysis; LDL, low-density lipoprotein; MBE, malignant brain edema; MCA, middle cerebral artery; mTICI, modified Thrombolysis In Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale; OTP, symptom onset to groin puncture time; OTR, time from stroke onset to recanalization; SBP, systolic blood pressure; TOAST, the Trial of ORG 10172 in Acute Stroke.