Results of the univariable and multivariable logistic regression for MBE after endovascular thrombectomy in the training cohort
| Univariable | Multivariable | |||||
| MBE | Non-MBE | P value | Regression coefficient | OR (95% CI) | P value | |
| n=135 | n=508 | |||||
| Age, years, mean (SD) | 66 (12.1) | 67 (11.4) | 0.427 | |||
| Men, n (%) | 81 (60.0) | 313 (61.6) | 0.732 | |||
| Hypertension, n (%) | 106 (78.5) | 322 (63.4) | 0.001 | 0.704 | 2.022 (1.184 to 3.451) | 0.010 |
| Diabetes, n (%) | 29 (21.5) | 82 (16.1) | 0.145 | |||
| Atrial fibrillation, n (%) | 69 (51.1) | 228 (44.9) | 0.197 | |||
| Baseline SBP, mm Hg, median (IQR) | 150 (133–165) | 149 (129–160) | 0.256 | |||
| Baseline DBP, mm Hg, median (IQR) | 84 (72–92) | 81 (74–91) | 0.714 | |||
| Baseline NIHSS score, median (IQR) | 18 (16–22) | 15 (12–19) | <0.001 | 0.052 | 1.053 (1.010 to 1.099) | 0.015 |
| Baseline ASPECT score, median (IQR) | 8 (5–9) | 9 (8–10) | <0.001 | −0.271 | 0.763 (0.682 to 0.852) | <0.001 |
| IVT, n (%) | 42 (31.1) | 107 (21.1) | 0.014 | 0.602 | 1.825 (1.095 to 3.042) | 0.021 |
| TOAST classification, n (%) | 0.090 | |||||
| Atherosclerotic | 36 (26.7) | 186 (36.6) | ||||
| Cardioembolic | 78 (57.8) | 259 (51.0) | ||||
| Others | 21 (15.6) | 63 (12.4) | ||||
| OTP, min, median (IQR) | 279 (218–330) | 279 (219–359) | 0.697 | |||
| OTR, min, median (IQR) | 380 (310–452) | 355 (285–445) | 0.127 | |||
| Collateral status, n (%) | <0.001 | |||||
| Poor | 111 (82.2) | 240 (47.5) | −1.106 | Reference | ||
| Good | 24 (17.8) | 268 (52.8) | 0.331 (0.195 to 0.561) | <0.001 | ||
| First-line treatment, n (%) | 0.078 | |||||
| Stent retriever | 89 (65.9) | 338 (66.7) | ||||
| Contact aspiration | 35 (25.9) | 98 (19.3) | ||||
| Angioplasty or stent | 11 (8.1) | 71(14) | ||||
| mTICI 2b-3, n (%) | 87 (64.4) | 445 (87.6) | <0.001 | −1.095 | 0.334 (0.199 to 0.563) | <0.001 |
| Tandem, n (%) | 21 (15.6) | 85 (16.7) | 0.743 | |||
| Occlusion site, n (%) | <0.001 | |||||
| MCA | 42 (31.1) | 314 (61.8) | −0.962 | 0.382 (0.241 to 0.606) | <0.001 | |
| ICA | 93 (68.9) | 194 (38.2) | Reference | |||
| FBG, mmol/L, median (IQR) | 7.7 (6.0–10.1) | 6.0 (5.1–7.6) | <0.001 | 0.117 | 1.124 (1.051 to 1.202) | 0.001 |
| LDL, mmol/L, median (IQR) | 2.3 (1.8–2.9) | 2.3 (1.9–2.9) | 0.691 | |||
| BUN, mmol/L, median (IQR) | 5.7 (4.6–8.0) | 5.6 (4.5–7.1) | 0.321 | |||
| Cr, μmol/l, median (IQR) | 75.0 (63.0–99.5) | 74.0 (60.7–92.9) | 0.187 | |||
ASPECT, Alberta Stroke Program Early CT; BUN, blood urea nitrogen; Cr, creatinine; DBP, diastolic blood pressure; FBG, fasting blood glucose; ICA, internal carotid artery; IVT, intravenous thrombolysis; LDL, low-density lipoprotein; MBE, malignant brain edema; MCA, middle cerebral artery; mTICI, modified Thrombolysis In Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale; OTP, symptom onset to groin puncture time; OTR, time from stroke onset to recanalization; SBP, systolic blood pressure; TOAST, the Trial of ORG 10172 in Acute Stroke.