Comparison of outcomes between COVID-19-positive unvaccinated vs. fully vaccinated patients presenting with stroke.*Adjusted for hypertension, atrial fibrillation, PVD, admission NIHSS, ASPECTS, tandem occlusion, and thrombectomy
| Unvaccinated | Vaccinated | Effect Variable | Unadjusted Value (95% CI) | Unadjusted p-value | Adjusted Value (95% CI)* | Adjusted p-value* | |
|---|---|---|---|---|---|---|---|
| Primary Outcome | |||||||
| mRS at discharge, median (IQR) | 4 (2–5) | 3 (1–4) | Common Odds Ratio | 0.508 (0.301–0.859) | 0.011 | 0.490 (0.211–1.139) | 0.098 |
| Secondary Outcomes | |||||||
| mRS 0–1 at discharge, n (%) | 32/134 (23.9) | 24/64 (37.5) | Odds Ratio | 1.913 (1.005-3.639) | 0.048 | 1.733 (0.583–5.149) | 0.322 |
| mRS 0–2 at discharge, n (%) | 41/134 (30.6) | 29/64 (45.3) | Odds Ratio | 1.879 (1.017–3.473) | 0.044 | 2.278 (0.757–6.858) | 0.143 |
| NIHSS at 24 hours, median (IQR) | 6 (1–19) | 3 (1–8) | Beta | -4.062 (-7.072– -1.053) | 0.008 | -1.919 (-4.362–0.524) | 0.122 |
| NIHSS at discharge, median (IQR) | 6 (1–21) | 2 (0–6) | Beta | -6.882 (-11.363– -2.401) | 0.003 | -3.589 (-8.490–1.312) | 0.149 |
| Mortality at discharge, n (%) | 27/134 (20.2) | 5/64 (7.8) | Odds Ratio | 0.336 (0.123–0.918) | 0.033 | 0.556 (0.069–4.479) | 0.581 |
| mRS at 3 months, median (IQR) | 6 (3–6) | 6 (1–6) | Common Odds Ratio | 0.872 (0.251–3.035) | 0.830 | 0.882 (0.110–7.085) | 0.906 |
| mRS 0–1 at 3 months, n (%) | 10/55 (18.2) | 3/11 (27.3) | Odds Ratio | 1.688 (0.379–7.513) | 0.492 | 2.365 (0.167–33.495) | 0.524 |
| mRS 0–2 at 3 months, n (%) | 12/55 (21.8) | 4/11 (36.4) | Odds Ratio | 2.048 (0.512–8.181) | 0.311 | 3.177 (0.246–40.962) | 0.376 |
| Mortality at 3 months, n (%) | 28/55 (50.9) | 6/11 (54.6) | Odds Ratio | 1.157 (0.316–4.243) | 0.826 | 3.646 (0.184–72.275) | 0.396 |
| NIHSS at 3 months, median (IQR) | 42 (5–42) | 42 (0–42) | Beta | -1.756 (-15.762–12.251) | 0.802 | 4.187 (-17.203–25.576) | 0.690 |
| Decompressive craniectomy, n (%) | 6/136 (4.4) | 0/62 (0) | –– | –– | 0.180 | –– | –– |
| Length of hospital stay, median (IQR) days | 6 (3–14) | 5 (3–10) | Beta | -3.761 (-6.577– -0.944) | 0.009 | -4.364 (-8.895–0.168) | 0.059 |