Table 3

Interaction analysis regarding primary and secondary outcomes according to overall and in-hospital delays

Time	Outcome category	Outcome	aOR for MT alone per 1 hour delay with 95% CI	aOR of interaction per 1 hour delay with 95% CI*
*Onset-to-needle time:** Expected time from symptom onset or last known well to IVT bolus	Efficacy	mRS 0–2 (primary), day 90	0.86, 0.60 to 1.23	0.76, 0.45 to 1.30
		mRS decrease (better outcome), day 90	0.82, 0.60 to 1.12	0.90, 0.58 to 1.39
		Mortality, day 90	1.57, 0.91 to 2.70	0.98, 0.42 to 2.32
	Safety	Any ICH on 24 hours imaging	1.35, 0.93 to 1.97	1.33, 0.78 to 2.27
	Safety	Symptomatic ICH on 24 hours imaging	1.15, 0.42 to 3.17	0.66, 0.17 to 2.65
	Pharmacological efficacy	Pre-interventional reperfusion success (cs-eTICI ≥2a)	0.99, 0.40 to 2.42	1.56, 0.54 to 4.49
		Time-to-reperfusion	0.73, 0.60 to 0.89	1.24, 0.94 to 1.62,
		Final reperfusion success (cs-eTICI ≥2b)	0.78, 0.44 to 1.37	1.04, 0.36 to 3.02
*Door-to-needle time:** Expected time from arrival at the emergency department door to IVT bolus	Efficacy	mRS 0–2 (primary), day 90	1.47, 0.60 to 3.56	0.48, 0.14 to 1.62
		mRS decrease (better outcome), day 90	1.88, 0.91 to 3.88	0.36, 0.13 to 0.99
		Mortality, day 90	0.11, 0.02 to 0.66	17.8, 1.8 to 174.9
	Safety	Any ICH on 24 hours imaging	0.99, 0.40 to 2.43	0.95, 0.28 to 3.24
	Safety	Symptomatic ICH on 24 hours imaging	0.73, 0.05 to 10.74	4.60, 0.19 to 114.10
	Pharmacological efficacy	Pre-interventional reperfusion success (cs-eTICI ≥2a)	2.26, 0.36 to 14.38	0.63, 0.07 to 6.06
		Time-to-reperfusion	0.40, 0.26 to 0.63	0.88, 0.47 to 1.64
		Final reperfusion success (cs-eTICI ≥2b)	1.69, 0.37 to 7.81	0.56, 0.05 to 6.83

*The aOR indicates the interaction term of assignment to IVT+MT (as compared with MT alone) and 1 hour delay and group assignment assuming a linear effect. The OR for MT alone gives the change in the odds for functional independence per additional hour delay. The interaction refers to change in the treatment effect (odds for functional independence of IVT plus MT vs MT alone) per additional hour delay.
aOR, adjusted OR; cs-eTICI, cross-sectional expanded Thrombolysis In Cerebral Infarction; ICH, intracranial hemorrhage; IVT, intravenous thrombolysis; mRS, modified Rankin Scale; MT, mechanical thrombectomy.