Table 1

Rates of safety from the literature for endovascular treatment of unruptured and ruptured aneurysms

N
Aneurysms (subjects)
Mortality at dischargeOverall complication rateRupture/ perforation rate
(%)
Embolism rate (%)
Ruptured intracranial aneurysms
 Algra et al 2019* 3373 066 (71 819)0.3% (0.2–0.4%)4.96% (4.00, 6.12%)0.9% (212/18 520)
95% CI (0.6% to 1.3%)
2.82% (437/16 000) 95% CI (2.3% to 3.5%)
 Advanced endovascular methods†3322480.4% (0.2–1.1%)6.1% (4.3, 8.7%)
 Kawbata et al 2018341406 (1375)1.4% (20/1406)
 Coil only3401.8% (6/340)
 Stent-assisted coiling4680.9% (4/468)
 Balloon-assisted coiling5981.7% (10/598)
 From lit review, table 6 in Kawbata3477850%1.4% (108/7785)
 Zheng et al 20163511271% (11/1127)
 Santillan et al 2013 362170%1.1% (3/217)
 Shigematsu et al 20133747671.4% (65/4767)
 Oishi et al 2012385000%1.4% (7/500)
 Im et al 2009394350%0.9% (4/435)
 Pierot et al 200840739 (649)0.3%2.4% (18/739)7.3% (29/398)
 (ATENA study)(700 procs)1.4% (1 month)15.4%2.6% (18/700)7.1% (per proc)
  Pierot et al 200941
  (ATENA study, coil alone results)
3250.9% (3/325)10.8% (35/325)2.1% (7/325)6.2% (20/325)
Ruptured intracranial aneurysms
 Zhang et al 2019421004All cause 9.5% (5.8%, 13.2%) procedure related 1.8% (0.9, 2.7%)22.7%‡ 95% CI (15.1% to 30.3%)
  Cognard et al 201143
  (CLARITY GDC study)
4051.50%3.7% (15/405)13.3% (54/405)
 Pierot et al 2011 (CLARITY)446085.1% (31/608) cum. treatment-related morbidity/mortality rate
19.6% (119/608) with. morbidity/mortality rate)
17.4% (106/608)4.6% (28/608)
  • *Rates presented are pooled crude risk from meta-analysis modeling.

  • †Advanced=stent-assisted coiling, balloon-assisted coiling, flow diverting stents or Woven Endobridge devices.

  • ‡Definition not specified.