Table 1

Clinical characteristics and mortality according to troponin dynamic changes

hs-cTnI dynamic changesP value
Yes (n=90)No (n=264)
Age >70 years, n (%)65 (72.2)138 (52.3) 0.001
Male, n (%)44 (48.9)163 (61.7) 0.033
Vascular risk factors
 Hypertension, n (%)62 (68.9)168 (63.6)0.367
 Diabetes mellitus, n (%)24 (26.7)74 (28.0)0.803
 Current smoking, n (%)11 (12.2)47 (17.8)0.217
Comorbidities
 AF, n (%)56 (62.2)123 (46.6) 0.010
 CAD, n (%)15 (16.7)24 (9.1) 0.047
 Previous stroke, n (%)19 (21.1)43 (16.3)0.299
Treatment status
 Previous antithrombotic therapy, n (%)22 (24.4)40 (15.2) 0.045
 OTA, min (IQR)89 (57–224)107 (60–240)0.549
 Transfers, n (%)9 (10)39 (14.8)0.253
 Use of IV rtPA, n (%)21 (23.3)73 (27.7)0.423
 Poor reperfusion, n (%)22 (24.4)43 (16.3)0.084
 Dual antiplatelet therapy, n (%)5 (5.6)36 (13.6) 0.039
NIHSS on admission 0.001
 0–8*, n (%)3 (3.3)42 (15.9)
 9–16, n (%)29 (32.2)103 (39.0)0.021†
 >16, n (%)58 (64.4)119 (45.1) <0.001
Laboratory tests
 Baseline blood glucose, mmol/L (IQR)7.15 (6.30–8.50)7.10 (6.10–8.80)0.921
 HbA1c,% (IQR)6.00 (5.50–6.50)5.90 (5.50–7.00)0.754
 HCY, μmol/L (IQR)15.43 (11.41–20.05)13.25 (9.91–18.20)0.068
 Platelets, 109/L (IQR)176 (150–219)199 (160–235) 0.036
 INR (IQR)1.04 (0.98–1.12)1.02 (0.94–1.09) 0.022
 LDL-C, mmol/L (IQR)2.32 (1.83–3.16)2.63 (1.95–3.39)0.083
 eGFR, L/min/1.73 m2 (IQR)53.81 (42.04–75.90)66.32 (48.59–80.99) 0.002
Stroke location
 Posterior circulation, n (%)33 (36.7)84 (31.8)0.398
 Insula‡, n (%)12 (14.1)51 (19.6)0.255
 ICH‡25 (29.4)86 (33.1) 0.530
 sICH‡22 (25.9)69 (26.5) 0.905
Mortality§, n (%)37 (45.7)57 (23.5) <0.001
  • *Control group.

  • †P<0.017 was statistically significant.

  • ‡Data were available in 345 patients.

  • §Data were available in 324 patients.

  • AF, atrial fibrillation; CAD, coronary artery disease; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HCY, homocysteine; hs-cTnI, high-sensitivity cardiac troponin; ICH, intracranial hemorrhage; INR, international normalized ratio; IQR, interquartile range; LDL-C, low-density lipoprotein; NIHSS, National Institutes of Health Stroke Scale score; OTA, onset-to-admission time; IV rtPA, intravenous recombinant tissue plasminogen activator; sICH, symptomatic intracranial hemorrhage.