Table 2

Reversal agents for anticoagulants

AnticoagulantReversal agent
HeparinProtamine sulfate
LMWHProtamine sulfate (partial reversal)
WarfarinVitamin K
DabigatranIdarucizumab
ApixabanAndexanet alfa
EdoxabanAndexanet alfa
Rivaroxaban (higher doses)Andexanet alfa
  • No data show that fast reversal of a direct oral anticoagulant leads to a better clinical outcome.96

  • LMWH, low molecular weight heparin.