Primary and secondary outcomes in inpatient cases with ruptured intracranial aneurysms
| Endovascular therapy (EVT) | Neurosurgical clipping (NSC) | EVT+NSC | OR (EVT vs NSC) | aOR* (EVT vs NSC) | |
| Inpatient cases with ruptured aneurysms, N | 26 955 | 18 601 | 1386 | ||
| Primary endpoints | |||||
| Functional outcome at discharge (ordinal endpoint) | 0.83 (95% CI 0.76 to 0.90, p<0.001) | 0.81 (95% CI 0.75 to 0.88, p<0.001) | |||
| Good (discharge to home) | 35.94% | 29.53% | 26.70% | ||
| Intermediate (further hospital /rehab/nursing home) | 46.54% | 53.15% | 57.14% | ||
| Poor (intrahospital death) | 17.51% | 17.32% | 16.16% | ||
| In-hospital mortality | 17.51% | 17.32% | 16.16% | 1.01 (95% CI 0.93 to 1.11, p .767) | 0.98 (95% CI 0.90 to 1.07, p .707) |
| NIS-SOM (modified Rankin Scale>3) | 38.67% | 47.64% | 51.23% | 0.69 (95% CI 0.63 to 0.76, p<0.001) | 0.67 (95% CI 0.61 to 0.74, p<0.001) |
| Secondary endpoints | |||||
| Length of stay (in days), mean±SD | 23.62±18.52 | 27.45±23.22 | 32.36±24.62 | ||
| Ventilation (in hours), mean±SD | 193.38±276.37 | 257.86±297.61 | 324.14±349.29 | ||
| Ventilation>48 hour | 49.34% | 62.19% | 70.20% | ||
| Reimbursement (in €), mean±SD (available since 2010) | 31 073±27 686 | 38 089±33 044 | 46 283±37 427 | ||
| n=refers only to reimbursement
(2010–2017) | 20 947 | 13 846 | 1082 |
*Primary endpoints were adjusted for age, sex, comorbidity (Charlson Comorbidity Index), and year of treatment (2007 to 2019) as potential confounders
aOR, adjusted OR; CI, confidence interval; EVT, endovascular treatment; NIS-SOM, National Inpatient Sample-Subarachnoid hemorrhage Outcome Measure; NSC, neurosurgical clipping; OR, odds ratio; SD, standard deviation.