Primary and secondary outcomes in inpatient cases with unruptured intracranial aneurysms
| Endovascular therapy (EVT) | Neurosurgical clipping (NSC) | EVT+NSC | OR (EVT vs NSC) | aOR* (EVT vs NSC) | |
| Inpatient cases with unruptured aneurysms, N | 29 410 | 13 377 | 310 | ||
| Primary endpoints | |||||
| Functional outcome at discharge (ordinal endpoint) | 0.44 (95% CI 0.38 to 0.52, p<0.001) | 0.40 (95% CI 0.35 to 0.47, p<0.001) | |||
| Good (discharge to home) | 92.39% | 84.20% | 60.32% | ||
| Intermediate (further hospital /rehab/nursing home) | 6.35% | 14.55% | 33.23% | ||
| Poor (intrahospital death) | 1.26% | 1.25% | 6.45% | ||
| In-hospital mortality | 1.26% | 1.25% | 6.45% | 1.01 (95% CI 0.80 to 1.27, p .947) | 0.92 (95% CI 0.73 to 1.16, p .482) |
| NIS-SOM (modified Rankin Scale>3) | 2.69% | 4.40% | 17.74% | 0.60 (95% CI 0.51 to 0.71, p<0.001) | 0.56 (95% CI 0.47 to 0.66, p<0.001) |
| Secondary endpoints | |||||
| Length of stay (in days), mean±SD | 7.06±7.21 | 13.60±10.48 | 23.15±17.96 | ||
| Ventilation (in hours), mean±SD | 11.31±77.44 | 26.19±120.00 | 107.28±230.46 | ||
| Ventilation >48 hour | 3.28% | 7.09% | 25.48% | ||
| Reimbursement (in €), mean±SD (available since 2010) | 10 567±8283 | 13 369±12 553 | 24 425±24 638 | ||
| n=refers only to reimbursement
(2010–2017) | 24 987 | 11 006 | 228 |
*Primary endpoints were adjusted for age, sex, comorbidity (Charlson index), and year of treatment (2007 to 2019) as potential confounders
aOR, adjusted OR; CI, confidence interval; EVT, endovascular treatment; NIS-SOM, National Inpatient Sample-Subarachnoid hemorrhage Outcome Measure; NSC, neurosurgical clipping; OR, odds ratio; SD, standard deviation.