Table 2

Clinical, technical, and safety outcomes

VariablesICA-TICA-IICA-EaOR*(95% CI)
ICA-I vs ICA-T
P valueaOR*(95% CI)
ICA-E vs ICA-T
P value
Clinical outcomes
mRS score at day 90, n (%)n=1478n=302n=235
 097 (6.6)20 (6.6)22 (9.4)Adjusted cOR
0.95
(0.74 to 1.22)
0.70 Adjusted cOR
0.70
(0.52 to 0.93)
0.01
 1133 (9.0)42 (13.9)21 (8.9)
 2130 (8.8)29 (9.6)23 (9.8)
 3174 (11.8)42 (13.9)23 (9.8)
 4215 (14.5)48 (15.9)35 (14.9)
 5138 (9.3)18 (6.0)21 (8.9)
 6591 (40.0)103 (34.1)90 (38.3)
mRS score ≤2 at day 90, n (%)360/1478 (24.4)91/302 (30.1)66/235 (28.1)0.87
(0.61 to 1.25)
0.460.69
(0.46 to 1.04)
0.08
mRS score ≤3 at day 90, n (%)534/1478 (36.1)133/302 (44.0)89/235 (37.9)1.05
(0.76 to 1.43)
0.78 0.64
(0.44 to 0.92)
0.02
Early neurologic improvement†, n (%)614/1644 (37.3)117/326 (35.9)79/241 (32.8)0.93
(0.71 to 1.21)
0.57 0.67
(0.48 to 0.92)
0.01
Early neurologic deterioration‡, n (%)359/1644 (21.8)71/326 (21.8)76/240 (31.7)0.90
(0.65 to 1.24)
0.51 1.70
(1.23 to 2.36)
<0.01
Technical outcomes
Successful recanalization (mTICI 2b/3), n (%)1628/1907 (85.4)287/357 (80.4)203/266 (76.3) 0.71
(0.53 to 0.95)
0.02 0.57
(0.42 to 0.78)
<0.001
Complete recanalization (mTICI 3), n (%)965/1907 (50.6)184/357 (51.5)131/266 (49.2)1.05
(0.84 to 1.32)
0.680.97
(0.75 to 1.26)
0.97
Successful recanalization (mTICI 2b/3) at first pass, n (%)576/1769 (32.6)106/325 (32.6)81/234 (34.6)1.01
(0.78 to 1.30)
0.941.12
(0.84 to 1.49)
0.45
Dissection/perforation during procedure§, n (%)59/1946 (3.0)16/366 (4.4)8/276 (2.9)1.44
(0.82 to 2.54)
0.210.95
(0.49 to 2.03)
0.90
Clot migration/embolization§, n (%)84/1946 (4.3)21/366 (5.7)26/276 (9.4)1.36
(0.83 to 2.23)
0.22 2.46
(1.55 to 3.92)
<0.001
Safety outcomes
Any ICH, n (%)241/1946 (12.4)35/366 (9.6)20/276 (7.2)0.86
(0.57 to 1.29)
0.450.66
(0.39 to 1.10)
0.11
Symptomatic ICH¶, n (%)84/1924 (4.4)14/360 (3.9)9/275 (3.3)0.95
(0.51 to 1.75)
0.860.88
(0.43 to 1.81)
0.73
Death during hospital stay, n (%)490/1793 (27.3)78/328 (23.8)74/256 (28.9)1.21
(0.87 to 1.67)
0.25 1.94
(1.37 to 2.74)
<0.001
Death at day 90, n (%)591/1478 (40.0)103/302 (34.1)90/235 (38.3)1.05
(0.76 to 1.45)
0.77 1.59
(1.11 to 2.28)
0.01
  • *Adjusted OR for lower mRS score, higher rates of early neurologic improvement/early neurologic deterioration, higher degree of recanalization, higher rates of dissection/perforation, clot migration/embolization, (symptomatic) ICH, death.

  • †∆NIHSS score ≥4 or NIHSS=0 at 24 hours.

  • ‡Worsening of NIHSS score ≥4 at 24 hours.

  • §Procedural complication as documented by the interventionalist.

  • ¶Any ICH on 24h follow up imaging and worsening of NIHSS score ≥4 at 24 hours.

  • ICH, intracranial hemorrhage; mRS, modified Rankin Scale; mTICI, modified Thrombolysis in Cerebral Infarction Scale; NIHSS, National Institutes of Health Stroke Scale.