Multivariate regression analysis of outcome and safety parameters for heparin bolus administration during endovascular treatment in anterior circulation stroke (ACS) patients (MR CLEAN-MED inclusion criteria), all ACS patients and all posterior circulation stroke patients.
| Parameter | ACS patients (MR CLEAN-MED inclusion criteria) | All ACS patients | All PCS patients | ||||||
| OR (95% CI) | ß (95% CI) | P-value | OR (95% CI) | ß (95% CI) | P-value | OR (95% CI) | ß (95% CI) | P-value | |
| mRS shift at 3 months* | 1.44 (1.06 to 1.96) | <0.05 | 1.13 (0.88 to 1.45) | 0.36 | 0.64 (0.32 to 1.30) | 0.21 | |||
| TICI 2b-3 reperfusion† | 0.60 (0.25 to 1.43) | 0.25 | 1.13 (0.65 to 1.94) | 0.67 | 1.36 (0.49 to 3.76) | 0.56 | |||
| TICI 3 reperfusion† | 0.96 (0.63 to 1.46) | 0.84 | 0.97 (0.74 to 1.28) | 0.84 | 1.08 (0.51 to 2.27) | 0.84 | |||
| NIHSS at 24 hours‡ | 2.74 (1.08 to 4.40) | <0.05 | 2.19 (1.03 to 3.35) | <0.05 | 1.95 (–2.06 to 5.96) | 0.39 | |||
| NIHSS at discharge‡ | 3.15 (1.41 to 4.89) | <0.05 | 3.67 (2.32 to 5.01) | <0.05 | 1.40 (–2.71 to 5.51) | 0.50 | |||
| Mortality at 3 months* | 0.86 (0.47 to 1.55) | 0.61 | 1.01 (0.70 to 1.46) | 0.95 | 0.75 (0.35 to 1.57) | 0.44 | |||
| ICH at 24 hours§ | 0.91 (0.50 to 1.67) | 0.76 | 0.69 (0.48 to 1.02) | 0.06 | 2.74 (0.36 to 20.81) | 0.33 | |||
*Adjusted for age, sex, pmRS, NIHSS, IVT, ASPECTS, BP diastolic, heart rate, hypertension, AF, dyslipidemia, SO to door, groin to reperfusion, SO to groin, type of vessel occlusion, retrieval attempts, and extracranial stenting (ACS patients with MR CLEAN-MED inclusion criteria); adjusted for age, sex, pmRS, NIHSS, IVT, door to groin, groin to reperfusion, door to reperfusion, risk factors; and overall complications (all ACS patients); adjusted for age, sex, pmRS, NIHSS, IVT, hypertension, diabetes, dyslipidemia, groin to reperfusion, door to reperfusion, number of passages, and ICH at 24 hours (PCS patients).
†Adjusted for age, sex, pmRS, NIHSS, hypertension, diabetes, dyslipidemia, BP systolic, ASPECTS, SO to door, door to groin, groin to reperfusion, carotid T occlusion, IVT, extracranial stenting, and retrieval attempts (ACS patients with MR CLEAN-MED inclusion criteria); adjusted for age, sex, pmRS, NIHSS, IVT, risk factors, door to groin, door to reperfusion, and groin to reperfusion (all ACS patients); adjusted for age, sex, pmRS, NIHSS, IVT, hypertension, diabetes, door to reperfusion, groin to reperfusion, and retrieval attempts (PCS patients).
‡Adjusted for age, sex, pmRS, NIHSS, ASPECTS, BP diastolic, heart rate, hypertension, AF, dyslipidemia, SO to door, groin to reperfusion, SO to groin, type of vessel occlusion, retrieval attempts, and extracranial stenting (ACS patients with MR CLEAN-MED inclusion criteria); adjusted for age, sex, pmRS, NIHSS, IVT, risk factors, door to groin, groin to reperfusion, door to reperfusion, and overall complications (all ACS patients); adjusted for age, sex, pmRS, NIHSS, IVT, diabetes, hypertension, dyslipidemia, groin to reperfusion, door to reperfusion, retrieval attempts, successful reperfusion, and ICH at 24 hours (PCS patients).
§Adjusted for age, sex, pmRS, NIHSS, IVT, ASPECTS, BP diastolic, heart rate, hypertension, AF, dyslipidemia, SO to door, groin to reperfusion, SO to groin, type of vessel occlusion, retrieval attempts, and extracranial stenting (ACS patients with MR CLEAN-MED inclusion criteria); adjusted for age, sex, pmRS, NIHSS, IVT, risk factors, door to groin, groin to reperfusion, and door to reperfusion (all ACS patients); adjusted for age, sex, pmRS, NIHSS, IVT, diabetes, dyslipidemia, hypertension, door to reperfusion, groin to reperfusion, retrieval attempts, and successful reperfusion (PCS patients).
ß, beta coefficient; ACS, anterior circulation stroke; AF, atrial fibrillation; ASPECTS, Alberta Stroke Program Early CT Score; BP, blood pressure; CI, confidence interval; ICH, intracranial hemorrhage; IVT, intravenous thrombolysis ; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; OR, odds ratio; PCS, posterior circulation stroke; pmRS, premodified Rankin Scale; SO, stroke onset; TICI, Thrombolysis In Cerebral Infarction.