Time since last known well for patients enrolled in large ischemic core trials
| RESCUE-Japan LIMIT (EVT vs MM) | SELECT2 (EVT vs MM) | ASPECT-ANGEL (EVT vs MM) | |
| LKW, eligibility criteria | Either 0–6 hours or 6–24 hours without hyperintensity on FLAIR-MRI | 0–24 hours | 0–24 hours |
| Actual LKW to randomization | 229 min vs 214 min | 9.79 hours vs 9.07 hours | 453 min vs 463 min |
| Percentage of patients in 6–24 hour time window | 28.6% | 71.6% | 63.3% |
| TESLA | LASTE | TENSION | |
| LKW, eligibility criteria | 0–24 hours | 0–6.5 hours | 0–12 hours |
| Actual LKW to randomization | Not reported | 271 min vs 268 min | 120 min vs 126 min |
| Percentage of patients in the 6–24 hour time window | 72.4% vs 72.3% | Data presented for >6.5 hours 16.4% vs 12.1% (eligibility required presentation within 7 hours of LKW or unknown LKW with negative FLAIR) | N/A; 47.2% of patients in 6–11 hour cohort, 50.5% of whom underwent EVT and 49.5% underwent MM |
EVT, endovascular therapy; LKW, last known well; MM, medical management.