GRADE evidence profile for PICO 7
| Certainty assessment | № of patients | Effect | Certainty | Importance | ||||||||
| № of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Direct EVT | IVT+ | Relative (95% CI) | Absolute (95% CI) | ||
| mRS 0–3 at 90 days observational | ||||||||||||
| 2 | Non-randomized studies | Serious* | Not serious | Not serious | Serious† | None | 154/436 (35.3%) | 81/196 (41.3%) | OR 0.75 (0.50 to 1.12) | 68 fewer per 1000 (from 153 fewer to 28 more) | ⨁⨁◯◯Low | CRITICAL |
| mRS 0–2 at 90 days observational | ||||||||||||
| 5 | Non-randomized studies | Serious‡ | Not serious | Not serious | Serious† | None | 272/682 (39.9%) | 161/360 (44.7%) | OR 0.70 (0.48 to 1.05) | 86 fewer per 1000 (from 168 fewer to 12 more) | ⨁⨁◯◯Low | CRITICAL |
| shift mRS 90 days observational | ||||||||||||
| 3 | Non-randomized studies | Serious* | Not serious | Not serious | Serious† | None | OR 0.58 (0.37 to 0.90) | One fewer per 1000 (from 1 fewer to 0 fewer) | ⨁⨁◯◯Low | CRITICAL | ||
| TICI 2B/3 90 days observational | ||||||||||||
| 4 | Non-randomized studies | Serious* | Not serious | Not serious | Serious† | None | 604/754 (80.1%) | 308/371 (83.0%) | OR 0.89 (0.40 to 1.96) | 17 fewer per 1000 (from 169 fewer to 75 more) | ⨁⨁◯◯Low | CRITICAL |
| sICH observational | ||||||||||||
| 4 | Non-randomized studies | Serious* | Not serious | Not serious | Serious† | None | 41/741 (5.5%) | 18/363 (5.0%) | OR 1.20 (0.35 to 4.07) | Nine more per 1000 (from 32 fewer to 126 more) | ⨁⨁◯◯Low | CRITICAL |
*Serious risk of bias due to serious confounding reported in both studies implemented for this outcome according to ROBINS-I tool for observational studies.
† Serious imprecision due to low optimal information size. The total number of patients included is less than the number of patients generated by a conventional size sample calculation for a single adequately powered clinical trial.
‡Serious risk of bias due to serious confounding reported in studies implemented for this outcome according to ROBINS-I tool for observational studies.
CI, confidence interval; EVT, give details; mRS, modified Rankin Scale; OR, give details; OR, odds ratio; sICH, give details; TICI, give details.