GRADE evidence profile for PICO 10
| Certainty assessment | № of patients | Effect | Certainty | Importance | ||||||||
| № of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | add-on antithrombotic treatment | No add-on antithrombotic treatment | Relative (95% CI) | Absolute (95% CI) | ||
| mRS 0–2 at 90 days: Observational studies | ||||||||||||
| 7 | Observational studies | Serious* | Not serious | Not serious | Not serious | None | OR 1.02 (0.77 to 1.35) | One fewer per 1000 (from 1 fewer to one fewer) | ⨁◯◯◯Very low | IMPORTANT | ||
| Mortality at 90 days: Observational studies | ||||||||||||
| 7 | Observational studies | Serious* | Not serious | Not serious | Not serious | None | 222/652 (34.0%) | 232/516 (45.0%) | OR 0.68 (0.45 to 1.01) | 92 fewer per 1000 (from 181 fewer to two more) | ⨁◯◯◯Very low | CRITICAL |
| Symptomatic Intracranial Haemorrhage (sICH): Observational studies | ||||||||||||
| 7 | Observational studies | Serious* | Not serious | Not serious | Not serious | None | 31/654 (4.7%) | 40/519 (7.7%) | OR 0.68 (0.34 to 1.34) | 23 fewer per 1000 (from 46 fewer to 24 more) | ⨁◯◯◯Very low | CRITICAL |
| mTICI: Observational studies | ||||||||||||
| 7 | Observational studies | Serious* | Not serious | Not serious | Not serious | None | OR 1.72 (1.01 to 2.95) | Two fewer per 1000 (from 3 fewer to one fewer) | ⨁◯◯◯Very low | IMPORTANT | ||
*Serious risk of bias due to serious confounding reported in studies implemented for this outcome according to ROBINS-I tool for observational studies.
CI, confidence interval; mRS, modified Rankin Scale; mTICI, modified Thrombolysis in Cerebral Ischemia; OR, odds ratio.