After propensity score matching | OR (95% CI) | |||||||
Patients, number (%) | ||||||||
All (n=226) | mTICI 2b (n=113) | mTICI 3 (n=113) | P value* | Unadjusted†† | P value | Adjusted‡‡ | P value | |
Primary outcome | ||||||||
90-day mRS score, median (IQR) | 4 (3–6) | 4 (3–6) | 4 (2–6) | 0.71† | 1.09 (0.69 to 1.74)§ | 0.71 | 1.12 (0.64 to 1.94)§ | 0.70 |
Secondary outcomes | ||||||||
Independent ambulation (90-day mRS score 0–3) | 89/226 (39.4%) | 45/113 (39.8%) | 44/113 (38.9%) | 0.89‡ | 0.96 (0.56 to 1.64) | 0.89 | 0.82 (0.38 to 1.72) | 0.60 |
Functional independence (90-day mRS score 0–2) | 55/226 (24.3%) | 26/113 (23.0%) | 29/113 (25.7%) | 0.64‡ | 1.16 (0.63 to 2.13) | 0.64 | 1.13 (0.51 to 2.52)¶ | 0.77 |
Safety outcomes | ||||||||
sICH within 24 hours | 19/221 (8.6%) | 14/111 (12.6%) | 5/110 (4.5%) | 0.03‡ | 0.33 (0.10 to 0.90) | 0.04 | NA** | NA** |
Mortality within 90 days | 80/226 (35.4%) | 42/113 (37.2%) | 38/113 (33.6%) | 0.58‡ | 0.86 (0.50 to 1.48) | 0.58 | 0.69 (0.33 to 1.45) | 0.33 |
*Characteristics were compared between mTICI 2b and mTICI 3 patients.
†Mann-Whitney U test for continuous variables.
‡χ2 test for categorical variables.
§Common ORs derived from ordinal logistic regression analysis. Values >1 indicate a shift in the distribution of 90-day mRS scores toward lower values (better functional outcomes) favoring mTICI 3 compared with mTICI 2b.
¶All patients with sICH did not achieve functional independence at 90 days (perfect prediction). Thus, the occurrence of sICH was not considered as covariate for this model.
**A multivariable regression analysis for sICH was not performed given the small number of cases (n=19).
††Univariable regression analysis with final mTICI grade (mTICI 2b vs mTICI 3) as independent variable. mTICI 2b was used as reference level.
‡‡Results were adjusted for age, sex, interval from last known well/symptom onset to hospital admission, admission NIHSS, ASPECTS, number of recanalization attempts, and occurrence of sICH within 24 hours.
mRS, modified Rankin Scale; mTICI, modified Thrombolysis In Cerebral Infarction; sICH, symptomatic intracranial hemorrhage.