Table 2

Functional and safety outcomes after propensity score matching

After propensity score matchingOR (95% CI)
Patients, number (%)
All
(n=226)
mTICI 2b
(n=113)
mTICI 3
(n=113)
P value*Unadjusted††P valueAdjusted‡‡P value
Primary outcome
 90-day mRS score, median (IQR)4 (3–6)4 (3–6)4 (2–6)0.71†1.09 (0.69 to 1.74)§0.711.12 (0.64 to 1.94)§0.70
Secondary outcomes
 Independent ambulation (90-day mRS score 0–3)89/226 (39.4%)45/113 (39.8%)44/113 (38.9%)0.89‡0.96 (0.56 to 1.64)0.890.82 (0.38 to 1.72)0.60
 Functional independence (90-day mRS score 0–2)55/226 (24.3%)26/113 (23.0%)29/113 (25.7%)0.64‡1.16 (0.63 to 2.13)0.641.13 (0.51 to 2.52)¶0.77
Safety outcomes
 sICH within 24 hours19/221 (8.6%)14/111 (12.6%)5/110 (4.5%)0.03‡0.33 (0.10 to 0.90)0.04NA**NA**
 Mortality within 90 days80/226 (35.4%)42/113 (37.2%)38/113 (33.6%)0.58‡0.86 (0.50 to 1.48)0.580.69 (0.33 to 1.45)0.33
  • *Characteristics were compared between mTICI 2b and mTICI 3 patients.

  • †Mann-Whitney U test for continuous variables.

  • ‡χ2 test for categorical variables.

  • §Common ORs derived from ordinal logistic regression analysis. Values >1 indicate a shift in the distribution of 90-day mRS scores toward lower values (better functional outcomes) favoring mTICI 3 compared with mTICI 2b.

  • ¶All patients with sICH did not achieve functional independence at 90 days (perfect prediction). Thus, the occurrence of sICH was not considered as covariate for this model.

  • **A multivariable regression analysis for sICH was not performed given the small number of cases (n=19).

  • ††Univariable regression analysis with final mTICI grade (mTICI 2b vs mTICI 3) as independent variable. mTICI 2b was used as reference level.

  • ‡‡Results were adjusted for age, sex, interval from last known well/symptom onset to hospital admission, admission NIHSS, ASPECTS, number of recanalization attempts, and occurrence of sICH within 24 hours.

  • mRS, modified Rankin Scale; mTICI, modified Thrombolysis In Cerebral Infarction; sICH, symptomatic intracranial hemorrhage.