Abstract
Although Guglielmi detachable coil (GDC) systems have been generally accepted for treatment of intracranial aneurysms, primary stenting of aneurysms using porous stents or implantation of coils after stent placement remains experimental. Testing of these new methods requires an animal model which imitates human aneurysms in size, configuration and neck morphology. We assessed in detail the technical requirements of and steps for transfemoral stent treatment of experimentally induced aneurysms at the top of the brachiocephalic trunk in rabbits. We created aneurysms in ten rabbits by distal ligation and intraluminal digestion of the right common carotid artery with elastase. We treated five animals with porous stents alone, and five with stents plus coiling via the meshes of the stent, which permitted dense packing of coils. No complications related to the procedures occurred. In all animals, even in those treated solely with porous stents, total occlusion of the aneurysm was achieved. Our animal model can be suitable for testing the biocompatibility and occlusion rate of new methods and devices for the treatment of experimental aneurysms.
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References
McCormick WF, Nofzinger JD (1965) Saccular intracranial aneurysms: An autopsy study. J Neurosurg 22: 155–159
Inagawa T, Hirano A (1990) Autopsy study of unruptured incidental intracranial aneurysms. Surg Neurol 34: 361–365
Nelson PK, Levy D, Masters LT, Bose A (1997) Neuroendovascular management of intracranial aneurysms. Neuroimaging Clin N Am 7: 739–762
Guglielmi G, Viñuela F, Sepetka I, Macellari V (1991) Electrothrombosis of saccular aneurysms via endovascular approach. Part 1: Electrochemical basis, technique, and experimental results. J Neurosurg 75: 1–7
Guglielmi G, Viñuela F, Dion J, Duckwiler G (1991) Electrothrombosis of saccular aneurysms via endovascular approach. Part 2: Preliminary clinical experience. J Neurosurg 75: 8–14
Geremia G, Brack T, Brennecke L, Haklin M, Falter R (2000) Occlusion of experimentally created fusiform aneurysms with porous metallic stents. AJNR 21: 739–745
Wakhloo AK, Schellhammer F, de Vries J, Haberstroh J, Schumacher M (1994) Self-expanding and balloon-expandable stents in the treatment of carotid aneurysms: an experimental study in a canine model. AJNR 15: 493–502
Szikora I, Guterman LR, Wells KM, Hopkins LN (1994) Combined use of stents and coils to treat experimental wide-necked carotid aneurysms: preliminary results. AJNR 15: 1091–1102
Lavine SD, Larsen DW, Giannotta SL, Teitelbaum GP (2000) Parent vessel Guglielmi detachable coil herniation during wide-necked aneurysm embolization: treatment with intracranial stent placement: two technical case reports. Neurosurgery 46: 1013–1017
Mericle RA, Lanzino G, Wakhloo AK, Guterman LR, Hopkins LN (1998) Stenting and secondary coiling of intracranial internal carotid artery aneurysm: technical case report. Neurosurgery 43: 1229–1234
Geremia G, Haklin M, Brennecke L (1994) Embolization of experimentally created aneurysms with intravascular stent devices. AJNR 15: 1223–1231
Link J, Feyerabend B, Grabener M, et al (1996) Dacron-covered stent-grafts for the percutaneous treatment of carotid aneurysms: effectiveness and biocompatibility—experimental study in swine. Radiology 200: 397–401
Altes TA, Cloft HJ, Short JG, et al (2000) 1999 ARRS Executive Council Award. Creation of saccular aneurysms in the rabbit: a model suitable for testing endovascular devices. Am J Roentgenol 174: 349–354
Kallmes DF, Helm GA, Hudson SB, et al (1999) Histologic evaluation of platinum coil embolization in an aneurysm model in rabbits. Radiology 213: 217–222
Cloft HJ, Altes TA, Marx WF, et al (1999) Endovascular creation of an in vivo bifurcation aneurysm model in rabbits. Radiology 213: 223–228
Miskolczi L, Guterman LR, Flaherty JD, Hopkins LN (1998) Saccular aneurysm induction by elastase digestion of the arterial wall: a new animal model. Neurosurgery 43: 595-600
Krings T, Moeller-Hartmann W, Hans FJ, et al (2003) A refined method for creating saccular aneurysms in the rabbit. Neuroradiology, in press
Reul J, Weis J, Spetzger U, Konert T, Fricke C, Thron A (1997) Long-term angiographic and histopathologic findings in experimental aneurysms of the carotid bifurcation embolized with platinum and tungsten coils. AJNR 18: 35–42
Moeller-Hartmann W, Krings T, Hans FJ, et al (2002) Endovascular treatment of experimental aneurysms in rabbits using Guglielmi detachable coils - A feasibility study. Neuroradiology 44: 946–949
Kallmes DF, Borland MK, Cloft HJ, et al (1998) In vitro proliferation and adhesion of basic fibroblast growth factor-producing fibroblasts on platinum coils. Radiology 206: 237–243
Turjman F, Massoud TF, Ji C, Guglielmi G, Viñuela F, Robert J (1994) Combined stent implantation and endosaccular coil placement for treatment of experimental wide-necked aneurysms: a feasibility study in swine. AJNR 15: 1087–1090
Acknowledgements
We greatly appreciate the help of Dr S. Kinzel concerning animal anaesthesia and of Professor W. Küpper, Dr H. Kommans, Dr C. Herweg, T. Stopinski and I. Hermanns concerning animal care. Without their dedication this work would not have been possible. This work was funded by the Stiftung Tumorforschung Kopf Hals, by the Deutsche Forschungsgemeinschaft (KR 2008/4-1), and by the Else Kröner-Fresenius-Stiftung.
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Hans, F.J., Krings, T., Möller-Hartmann, W. et al. Endovascular treatment of experimentally induced aneurysms in rabbits using stents: a feasibility study. Neuroradiology 45, 430–434 (2003). https://doi.org/10.1007/s00234-003-1008-y
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DOI: https://doi.org/10.1007/s00234-003-1008-y