The biological significance of platelet volume: Its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration

doi:10.1016/0049-3848(83)90255-4

Thrombosis Research

Volume 32, Issue 5, 1 December 1983, Pages 443-460

https://doi.org/10.1016/0049-3848(83)90255-4 Get rights and content

Abstract

Bleeding time, platelet thromboxane B₂ production and megakaryocyte nuclear DNA concentration were measured in rabbits recovering from thrombocytopenia caused by a single injection of anti-platelet serum. Similar measurements were made on rabbits in a steady state of normal platelet production. The effects of a sustained state of thrombocytopenia on megakaryocyte DNA concentration were investigated by repeated daily injections of anti-platelet serum. It is shown that bleeding time depends on both platelet count and mean platelet volume. Furthermore changes in mean platelet volume appear to play a more important role in haemostasis than changes in platelet count. The mean megakaryocyte nuclear DNA concentration is significantly increased after 24 hours of thrombocytopenia and continues to increase as thrombocytopenia is sustained. Thromboxane B₂ production/unit volume of platelet is increased in platelets produced after 24 hours of thrombocytopenia compared with platelets produced in normal steady state function. As a consequence platelets produced in response to thrombocytopenia not only have a larger mean platelet volume but are also more reactive. Mean platelet volume, as well as platelet count, should be considered as an index of haemostasis and its dysfunction, thrombosis.

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Citation Excerpt :
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PaperThe biological significance of platelet volume: Its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration

Abstract

Thrombosis Research

Thrombosis Research

Thrombosis Research

Blood

Thrombosis Research

Thrombosis Research.

Exp. Cell. Res.

Blood

The Lancet

The relation of blood platelets to haemorrhagic disease

Journal of the American Medical Assoc.

Thromboxanes — a new group of biologically active compounds derived from prostaglandin endoperoxides

Chemical studies of human platelet membranes

Paper
The biological significance of platelet volume: Its relationship to bleeding time, platelet thromboxane B₂ production and megakaryocyte nuclear DNA concentration