Systemic HypertensionRelation of Endothelium, Thrombogenesis, and Hemorheology in Systemic Hypertension to Ethnicity and Left Ventricular Hypertrophy☆
Section snippets
Patient Group:
We conducted a cross-sectional study of patients with hypertension attending our blood pressure clinic. Patients with hypertension were defined as those with blood pressure >160/90 mm Hg on ≥2 clinic visits, requiring eventual treatment with antihypertensive drugs. Careful documentation of clinical history and any antihypertensive therapy was recorded. Blood pressures were measured after sitting and 10 minutes rest in a quiet room by a trained observer using a Hawksley Random Zero
Results
We studied 178 consecutive patients (86 men; mean age 54 ± 15 years) with essential hypertension, in whom the LV mass index was determined using echocardiography; 103 were white, 49 were black and/or Afro-Caribbean, and 26 were Indo-Asian. Levels were compared with 47 matched normotensive healthy controls (mean age 56 ± 20 years).
Mean blood pressures were significantly higher in hypertensive patients compared with controls. There were significant elevations in plasma soluble P-selectin, vWf,
Discussion
Among hypertensive patients, it is well recognized that alterations in blood rheology are not uncommon in the clinical setting.11, 12In the MONICA-Project Augsburg study,[13]for example, a positive association was found between hypertension and plasma viscosity, whereas in the Scottish Health Heart Study,[14]blood viscosity, hematocrit, and plasma viscosity were correlated with blood pressure, independently of age, body mass index, and smoking status. In the present study, we found significant
Acknowledgements
Acknowledgment:
We thank J. Zarifis, MD, D. D. Bareford, MD, and Sister Michéle Beevers, SRN, for assistance with data collection.
References (28)
- et al.
The prevalence and correlates of echocardiographic left ventricular hypertrophy among employed patients with uncomplicated hypertension
J Am Coll Cardiol
(1986) - et al.
Cross-linked fibrin degradation products, progression of peripheral arterial disease, and risk of coronary heart disease
Lancet
(1993) - et al.
Is soluble P-selectin a new marker of platelet activation?
Atherosclerosis
(1997) Fibrinogen and cardiovascular disease
Quart J Med
(1995)- et al.
Fibrinogen as a cardiovascular risk factora meta-analysis and review of the literature
Ann Intern Med
(1993) - et al.
Fibrin D-dimerA useful clinical marker of thrombogenesis?
Clin Sci
(1995) - et al.
Plasminogen activator inhibitor in plasmarisk factor for recurrent myocardial infarction
Lancet
(1987) Platelet activation mechanisms and markers in arterial thrombosis
J Intern Med
(1996)- et al.
von Willebrand factor and its relevance to cardiovascular disorders
Br Heart J
(1995) - et al.
Lipoprotein (a) and vascular diseasethrombogenesis and atherogenesis
Quart J Med
(1995)
Hypertension detection and followup program
Summary of baseline characteristics of the hypertensive participants. Hypertension
Recommendations regarding quantitation in M-mode echocardiographyresults of a survey of echocardiographic measurements
Circulation
Abnormalities of rheology and coagulation in hypertension
J Hum Hypertens
Blood rheology in hypertension and hypertensive heart disease
J Cardiovasc Pharmacol
Cited by (149)
D-dimer and the risk of hypertension: The REasons for Geographic And Racial Differences in Stroke Cohort Study
2023, Research and Practice in Thrombosis and HaemostasisImmune system changes in those with hypertension when infected with SARS-CoV-2
2022, Cellular ImmunologyCitation Excerpt :Consequently, people with high blood pressure who have COVID-19 are more likely to develop myocardial damage and arrhythmias. Patients with hypertension have high plasma fibrinogen levels, impaired fibrinolysis, endothelial dysfunction, and favorable thrombosis [95]. Likewise, studies have suggested that COVID-19 is an endothelial disease, which can lead to clotting disorders [96].
Enhanced thrombin generation in patients with arterial hypertension
2019, Thrombosis ResearchIncreased platelet alpha<inf>2B</inf>-adrenergic receptor gene expression in well-controlled hypertensives: the effect of arterial stiffness
2017, Journal of the American Society of HypertensionCurrent Understanding of Atherogenesis
2017, American Journal of Medicine
- ☆
This study was supported by the British Heart Foundation (PG 94017), the Peel Medical Research Trust, London; and the Pulse Trust, Birmingham, United Kingdom.