Laboratory investigationHemolysis Comparison between the OmniSonics OmniWave Endovascular System and the Possis AngioJet in a Porcine Model
Section snippets
Procedure
Procedures were performed after receiving institutional IACUC approval in accordance with Good Laboratory Practices. The native-vessel nonthrombosed pig model was chosen because porcine weight, blood volume, and vessel diameters are comparable to that in adult humans. Twelve female Yorkshire swine with an average weight of 85.5 kg (range, 64.1–145 kg) were studied. Six were treated with the OmniWave device and six with the AngioJet connected to an Xpeedior-6 catheter (Possis). According to a
Baseline Characteristics
At baseline, animals in the OmniWave and AngioJet groups did not differ significantly from each other with regard to weight (P = .099), hematocrit level (P = .358), WBC count (P = .928), and platelet count (P = .250) (Table). Animals in the AngioJet group had a higher average baseline creatinine level (1.85 mg/dL ± 0.22 [163 μmol/L ± 19]) than those in the OmniWave group (1.53 mg/dL ± 0.18 [135 μmol/L ± 16]; P = .021), although all creatinine measurements were within the normal range for pigs
Discussion
The red cell membrane is composed of a metastable lipid bilayer. Shearing forces on the outer membrane can effect a transient opening of pores and, if they exceed a critical point, result in irreversible membrane rupture and lysis (17). Membrane deformation can be brought on by exposure to ultrasonic energy through the shearing forces of shock waves or flow effects from cavitation bubbles (as with the OmniWave) or shear stress from turbulent or steady flow through viscous and inertial fluid
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From the 2008 SIR annual meeting.
E.V.L., A.M.K, and R.B. are employees of OmniSonics Medical Technologies.
W.B. is a consultant for OmniSonics Medical Technologies. M.V. is an employee of DaVinci Biomedical.