Venous thromboembolism (VTE) is a common complication following acute ischemic and hemorrhagic stroke. Pulmonary embolism (PE), the most serious consequence of deep vein thrombosis (DVT), can result in significant morbidity and death. Patients with stroke are at particular risk because of limb paralysis, prolonged bed rest, and increased prothrombotic activity. Preventive measures should be taken at all levels of care and can include mechanical calf compression, antiplatelet agents, and the use of anticoagulants such as heparin and low molecular weight heparin. Prevention of VTE should be incorporated into all stroke care pathways.