Fatal hemorrhage during anticoagulation of cardioembolic infarction: role of cerebral amyloid angiopathy

Eur Neurol. 1993;33(1):9-12. doi: 10.1159/000116890.

Abstract

We report a patient with recurrent cardioembolism and hemorrhagic infarcts, who developed a fatal intracerebral hemorrhage 3 days after intravenous anticoagulation. At autopsy, cerebral amyloid angiopathy (CAA) was found. Because CAA and anticoagulation may add up to trigger cerebral hemorrhage, the possibility of underlying CAA should be raised before anticoagulating elderly patients with stroke.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aspirin / administration & dosage
  • Aspirin / adverse effects*
  • Cerebral Amyloid Angiopathy / complications*
  • Cerebral Amyloid Angiopathy / pathology
  • Cerebral Cortex / pathology
  • Cerebral Hemorrhage / chemically induced*
  • Cerebral Hemorrhage / pathology
  • Cerebral Infarction / drug therapy*
  • Cerebral Infarction / pathology
  • Female
  • Heart Ventricles / pathology
  • Heparin / administration & dosage
  • Heparin / adverse effects*
  • Humans
  • Hypertrophy, Left Ventricular / complications*
  • Hypertrophy, Left Ventricular / pathology
  • Intracranial Embolism and Thrombosis / drug therapy*
  • Intracranial Embolism and Thrombosis / pathology
  • Muscle, Smooth, Vascular / pathology

Substances

  • Heparin
  • Aspirin