Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …

Reversible interactions of glycoconjugates on leukocytes with P-and E-selectin on
endothelial cells mediate tethering and rolling of leukocytes in inflamed vascular beds, the …

Background Remdesivir improves clinical outcomes in patients hospitalized with moderate-
to-severe coronavirus disease 2019 (Covid-19). Whether the use of remdesivir in …

Hematopoietic stem and progenitor cells (HSPC), attracted by the chemokine CXCL12,
reside in specific niches in the bone marrow (BM). HSPC migration out of the BM is a critical …

Hematopoietic stem cells (HSCs) reside in specialized bone marrow (BM) niches regulated
by the sympathetic nervous system (SNS). Here, we have examined whether mononuclear …

Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of
the beating heart. It is unclear whether these cells, which are long-lived and rarely renew …

The induction of alloantigen-specific unresponsiveness remains an elusive goal in organ
transplantation. Here we identify plasmacytoid dendritic cells (pDCs) as phagocytic antigen …

Unique among leukocytes, neutrophils follow daily cycles of release from and migration
back into the bone marrow, where they are eliminated. Because removal of dying cells …

Immune and inflammatory responses require leukocytes to migrate within and through the
vasculature, a process that is facilitated by their capacity to switch to a polarized morphology …