PARP inhibition: PARP1 and beyond
Recent findings have thrust poly (ADP-ribose) polymerases (PARPs) into the limelight as
potential chemotherapeutic targets. To provide a framework for understanding these recent …
potential chemotherapeutic targets. To provide a framework for understanding these recent …
[HTML][HTML] Nanotechnology in wastewater management: a new paradigm towards wastewater treatment
Clean and safe water is a fundamental human need for multi-faceted development of society
and a thriving economy. Brisk rises in populations, expanding industrialization, urbanization …
and a thriving economy. Brisk rises in populations, expanding industrialization, urbanization …
Talimogene laherparepvec (T-VEC) and other oncolytic viruses for the treatment of melanoma
PK Bommareddy, A Patel, S Hossain… - American journal of …, 2017 - Springer
Many mammalian viruses have properties that can be commandeered for the treatment of
cancer. These characteristics include preferential infection and replication in tumor cells, the …
cancer. These characteristics include preferential infection and replication in tumor cells, the …
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
To understand the pathogenesis of chronic inflammatory disease, we analyzed an
experimental mouse model of chronic lung disease with pathology that resembles asthma …
experimental mouse model of chronic lung disease with pathology that resembles asthma …
Nonhomologous end joining drives poly (ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells
AG Patel, JN Sarkaria… - Proceedings of the …, 2011 - National Acad Sciences
Poly (ADP-ribose) polymerase (PARP) inhibitors are strikingly toxic to cells with defects in
homologous recombination (HR). The mechanistic basis for these findings is incompletely …
homologous recombination (HR). The mechanistic basis for these findings is incompletely …
The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis
AH Patel, DM Harnois, GG Klee, NF LaRusso… - The American journal of …, 2000 - Elsevier
OBJECTIVES: The diagnosis of cholangiocarcinoma is often difficult, making management
approaches problematic. A reliable serum tumor marker for cholangiocarcinoma would be a …
approaches problematic. A reliable serum tumor marker for cholangiocarcinoma would be a …
Marine bacterial, archaeal and protistan association networks reveal ecological linkages
Microbes have central roles in ocean food webs and global biogeochemical processes, yet
specific ecological relationships among these taxa are largely unknown. This is in part due …
specific ecological relationships among these taxa are largely unknown. This is in part due …
[HTML][HTML] A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq
(scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA …
(scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA …
Temperature triggered self-assembly of polypeptides into multivalent spherical micelles
MR Dreher, AJ Simnick, K Fischer… - Journal of the …, 2008 - ACS Publications
We report herein thermally responsive elastin-like polypeptides (ELPs) in a linear AB diblock
architecture with an N-terminal peptide ligand that self-assemble into spherical micelles …
architecture with an N-terminal peptide ligand that self-assemble into spherical micelles …
[HTML][HTML] Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease
Chronic obstructive lung disease is characterized by persistent abnormalities in epithelial
and immune cell function that are driven, at least in part, by infection. Analysis of …
and immune cell function that are driven, at least in part, by infection. Analysis of …