User profiles for "author:Benjamin Pulli"

Benjamin Pulli, MD

Massachusetts General Hospital & Harvard Medical School
Verified email at mgh.harvard.edu
Cited by 2328

Myeloperoxidase inhibition improves ventricular function and remodeling after experimental myocardial infarction

M Ali, B Pulli, G Courties, B Tricot, M Sebas… - JACC: Basic to …, 2016 - jacc.org
PF-1355 is an oral myeloperoxidase (MPO) inhibitor that successfully decreased elevated
MPO activity in mouse myocardial infarction models. Short duration PF-1355 treatment for 7 …

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model

SH Choi, E Bylykbashi, ZK Chatila, SW Lee, B Pulli… - Science, 2018 - science.org
INTRODUCTION Alzheimer's disease (AD) is the most common form of age-related
dementia, characterized by cognitive impairment, neurodegeneration, β-amyloid (Aβ) …

[HTML][HTML] Measuring myeloperoxidase activity in biological samples

B Pulli, M Ali, R Forghani, S Schob, KLC Hsieh… - PloS one, 2013 - journals.plos.org
Background Enzymatic activity measurements of the highly oxidative enzyme
myeloperoxidase (MPO), which is implicated in many diseases, are widely used in the …

Imaging-based treatment selection for intravenous and intra-arterial stroke therapies: a comprehensive review

AJ Yoo, B Pulli, RG Gonzalez - Expert review of cardiovascular …, 2011 - Taylor & Francis
Reperfusion therapy is the only approved treatment for acute ischemic stroke. The current
approach to patient selection is primarily based on the time from stroke symptom onset …

[HTML][HTML] Imaging neuroinflammation–from bench to bedside

B Pulli, JW Chen - Journal of clinical & cellular immunology, 2014 - ncbi.nlm.nih.gov
Neuroinflammation plays a central role in a variety of neurological diseases, including
stroke, multiple sclerosis, Alzheimer's disease, and malignant CNS neoplasms, among …

Myeloperoxidase–hepatocyte–stellate cell cross talk promotes hepatocyte injury and fibrosis in experimental nonalcoholic steatohepatitis

B Pulli, M Ali, Y Iwamoto, MWG Zeller… - Antioxidants & Redox …, 2015 - liebertpub.com
Abstract Aims: Myeloperoxidase (MPO), a highly oxidative enzyme secreted by leukocytes
has been implicated in human and experimental nonalcoholic steatohepatitis (NASH), but …

Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target

R Forghani, GR Wojtkiewicz, Y Zhang, D Seeburg… - Radiology, 2012 - pubs.rsna.org
Purpose To evaluate myeloperoxidase (MPO) as a newer therapeutic target and bis-5-
hydroxytryptamide-diethylenetriaminepentaacetate-gadolinium (Gd)(MPO-Gd) as an …

Acute ischemic stroke: infarct core estimation on CT angiography source images depends on CT angiography protocol

B Pulli, PW Schaefer, R Hakimelahi, ZA Chaudhry… - Radiology, 2012 - pubs.rsna.org
Purpose To test whether the relationship between acute ischemic infarct size on concurrent
computed tomographic (CT) angiography source images and diffusion-weighted (DW) …

Mouse model of anti-NMDA receptor post–herpes simplex encephalitis

J Linnoila, B Pulli, T Armangué… - Neurology …, 2018 - AAN Enterprises
Objective To develop an endogenous rodent model of postinfectious anti-NMDA receptor
(NMDAR) encephalitis. Methods Six mice were inoculated intranasally with herpes simplex …

Theranostic nanoparticles based on bioreducible polyethylenimine-coated iron oxide for reduction-responsive gene delivery and magnetic resonance imaging

D Li, X Tang, B Pulli, C Lin, P Zhao… - International journal …, 2014 - Taylor & Francis
Theranostic nanoparticles based on superparamagnetic iron oxide (SPIO) have a great
promise for tumor diagnosis and gene therapy. However, the availability of theranostic …