It has been demonstrated by numerous studies that apoptotic cell death pathways are
implicated in ischemic cerebral injury in ischemia models in vivo. Experimental ischemia …

Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading
causes of death and disability. Stem cell-based therapy is actively being investigated as a …

Background and Purpose—Hyperglycemia is linked to a worse outcome after ischemic
stroke. Among the manifestations of brain damage caused by ischemia are blood-brain …

To investigate the effect of an antioxidant edaravone on the apoptotic process, we examined
Bax and Bcl-2 immunohistochemical expression and terminal deoxynucleotidyl transferase …

Recent studies have revealed that the phosphatidylinositol 3-kinase (PI3-K) pathway is
involved in apoptotic cell death after experimental cerebral ischemia. The serine—threonine …

Although p53 is a key modulator of cellular stress responses, the mechanism of p53-
mediated apoptosis is ambiguous. p53 can mediate apoptosis in response to death stimuli …

Cytosolic phospholipase A2 (cPLA2) is a key enzyme that mediates arachidonic acid
metabolism, which causes cerebral ischemia-induced oxidative injury, blood—brain barrier …

Interleukin (IL)-10 is a contributing factor to neuroprotection of mesenchymal stem cell
(MSC) transplantation after ischemic stroke. Our aim was to increase therapeutic effects by …

Background and Purpose—Apoptotic cell death is associated with acute brain injury after
subarachnoid hemorrhage (SAH). The Akt/glycogen synthase kinase-3β (GSK3β) pathway …

Bad, a proapoptotic Bcl-2 family protein, plays a critical role in determining cell
death/survival. The phosphatidylinositol 3-kinase (PI3-K)/Akt pathway and the c-Jun N …