Random forests for genetic association studies
The Random Forests (RF) algorithm has become a commonly used machine learning
algorithm for genetic association studies. It is well suited for genetic applications since it is …
algorithm for genetic association studies. It is well suited for genetic applications since it is …
Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis
Atopic dermatitis (AD) has long been associated with Staphylococcus aureus skin
colonization or infection and is typically managed with regimens that include antimicrobial …
colonization or infection and is typically managed with regimens that include antimicrobial …
Super learner
MJ Van der Laan, EC Polley… - Statistical applications in …, 2007 - degruyter.com
When trying to learn a model for the prediction of an outcome given a set of covariates, a
statistician has many estimation procedures in their toolbox. A few examples of these …
statistician has many estimation procedures in their toolbox. A few examples of these …
[HTML][HTML] A population-based study of genes previously implicated in breast cancer
C Hu, SN Hart, R Gnanaolivu, H Huang… - … England Journal of …, 2021 - Mass Medical Soc
Background Population-based estimates of the risk of breast cancer associated with
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …
Associations between cancer predisposition testing panel genes and breast cancer
Importance Germline pathogenic variants inBRCA1andBRCA2predispose to an increased
lifetime risk of breast cancer. However, the relevance of germline variants in other genes …
lifetime risk of breast cancer. However, the relevance of germline variants in other genes …
Association between inherited germline mutations in cancer predisposition genes and risk of pancreatic cancer
Importance Individuals genetically predisposed to pancreatic cancer may benefit from early
detection. Genes that predispose to pancreatic cancer and the risks of pancreatic cancer …
detection. Genes that predispose to pancreatic cancer and the risks of pancreatic cancer …
Super learner in prediction
EC Polley, MJ Van der Laan - 2010 - biostats.bepress.com
Super learning is a general loss based learning method that has been proposed and
analyzed theoretically in van der Laan et al.(2007). In this article we consider super learning …
analyzed theoretically in van der Laan et al.(2007). In this article we consider super learning …
The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology
The NCI-60 cell lines are the most frequently studied human tumor cell lines in cancer
research. This panel has generated the most extensive cancer pharmacology database …
research. This panel has generated the most extensive cancer pharmacology database …
[HTML][HTML] Shifts in human skin and nares microbiota of healthy children and adults
Background Characterization of the topographical and temporal diversity of the microbial
collective (microbiome) hosted by healthy human skin established a reference for studying …
collective (microbiome) hosted by healthy human skin established a reference for studying …
[HTML][HTML] Interaction between the microbiome and TP53 in human lung cancer
Background Lung cancer is the leading cancer diagnosis worldwide and the number one
cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer …
cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer …