Stereoelectroencephalography (SEEG) was designed and developed in the 1960s in
France by J. Talairach and J. Bancaud. It is an invasive method of exploration for drug …

Background Surgery is a widely accepted treatment option for drug-resistant focal epilepsy.
A detailed analysis of longitudinal postoperative seizure outcomes and use of antiepileptic …

OBJECTIVE: Hemispherotomy techniques have been developed to reduce complication
rates and achieve the best possible seizure control. We present the results of our pediatric …

Genetic malformations of cortical development (MCDs), such as mild MCDs (mMCD), focal
cortical dysplasia (FCD), and hemimegalencephaly (HME), are major causes of severe …

Purpose To define the phenotypic and mutational spectrum of epilepsies related to
DEPDC5, NPRL2 and NPRL3 genes encoding the GATOR1 complex, a negative regulator …

Objective: To assess the prevalence of somatic MTOR mutations in focal cortical dysplasia
(FCD) and of germline MTOR mutations in a broad range of epilepsies. Methods: We …

Designed from the 60s to the 80s for adults, and despite the development of many new
techniques, invasive explorations still have indications in children with focal drug-resistant …

Focal malformations of cortical development (MCD) are linked to somatic brain mutations
occurring during neurodevelopment. Mild malformation of cortical development with …

OBJECTIVE: A small percentage of tuberous sclerosis patients will develop a subependymal
giant-cell astrocytoma. Given the morbidity and mortality when such a lesion is left …

Brain mosaic mutations are a major cause of refractory focal epilepsies with cortical
malformations such as focal cortical dysplasia, hemimegalencephaly, malformation of …