[HTML][HTML] Temporal regulation of apoptotic and anti-apoptotic molecules after middle cerebral artery occlusion followed by reperfusion

B Chelluboina, JD Klopfenstein, M Gujrati, JS Rao… - Molecular …, 2014 - Springer
A tremendous effort has been expended to elucidate the role of apoptotic molecules in
ischemia. However, many agents that target apoptosis, despite their proven efficacy in …

MMP-12, a promising therapeutic target for neurological diseases

B Chelluboina, KR Nalamolu, JD Klopfenstein… - Molecular …, 2018 - Springer
The role of matrix metalloproteinase-12 (MMP-12) in the pathogenesis of several
inflammatory diseases such as chronic obstructive pulmonary disease, emphysema, and …

[HTML][HTML] Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway

VR Dasari, K Kaur, KK Velpula, M Gujrati, D Fassett… - PloS one, 2010 - journals.plos.org
Background PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a
tumor suppressor gene implicated in a wide variety of human cancers, including …

Indications for surgical fusion of the cervical and lumbar motion segment

NC Bambakidis, I Feiz-Erfan, JD Klopfenstein… - Spine, 2005 - journals.lww.com
Study Design. A literature review and the authors' clinical experience for the indication of
fusion in the degenerative lumbar and cervical spine is provided. Objective. To establish …

Comparison of routine and selective use of intraoperative angiography during aneurysm surgery: a prospective assessment

JD Klopfenstein, RF Spetzler, LJ Kim, I Feiz-Erfan… - Journal of …, 2004 - thejns.org
Object Whether routine intraoperative angiography is necessary for cerebral aneurysm
surgery is currently under debate. In this study the authors prospectively assessed the …

Comparison of rapid and gradual weaning from external ventricular drainage in patients with aneurysmal subarachnoid hemorrhage: a prospective randomized trial

JD Klopfenstein, LJ Kim, I Feiz-Erfan, JS Hott… - Journal of …, 2004 - thejns.org
Object The goal of this study was to compare rapid and gradual weaning from external
ventricular drainage in patients with aneurysmal subarachnoid hemorrhage (SAH) in a …

[HTML][HTML] MMP-2 siRNA inhibits radiation-enhanced invasiveness in glioma cells

AV Badiga, C Chetty, D Kesanakurti, D Are, M Gujrati… - PloS one, 2011 - journals.plos.org
Background Our previous work and that of others strongly suggests a relationship between
the infiltrative phenotype of gliomas and the expression of MMP-2. Radiation therapy, which …

Intraoperative Iso-C C-arm navigation in craniospinal surgery: the first 60 cases

JS Hott, VR Deshmukh, JD Klopfenstein… - …, 2004 - journals.lww.com
OBJECTIVE: The intraoperative Iso-C C-arm (Siremobil Iso-C 3D; Siemens Medical
Solutions, Erlangen, Germany) provides a unique ability to acquire and view multi-planar …

[HTML][HTML] Cord blood stem cell-mediated induction of apoptosis in glioma downregulates X-linked inhibitor of apoptosis protein (XIAP)

VR Dasari, KK Velpula, K Kaur, D Fassett… - PloS one, 2010 - journals.plos.org
Background XIAP (X-linked inhibitor of apoptosis protein) is one of the most important
members of the apoptosis inhibitor family. XIAP is upregulated in various malignancies …

Chk2-mediated G2/M cell cycle arrest maintains radiation resistance in malignant meningioma cells

VR Gogineni, AK Nalla, R Gupta, DH Dinh… - Cancer letters, 2011 - Elsevier
In continuation to our studies on radioresistance in meningioma, here we show that radiation
treatment (7Gy) induces G2/M cell cycle arrest in meningioma cells. Phosphorylation of …