Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a …

MDI Vergouwen, M Vermeulen, J van Gijn, GJE Rinkel… - Stroke, 2010 - Am Heart Assoc
Background and Purpose—In clinical trials and observational studies there is considerable
inconsistency in the use of definitions to describe delayed cerebral ischemia (DCI) after …

Clinical trials in head injury

RK Narayan, ME Michel, B Ansell… - Journal of …, 2002 - liebertpub.com
Traumatic brain injury (TBI) remains a major public health problem globally. In the United
States the incidence of closed head injuries admitted to hospitals is conservatively estimated …

[PDF][PDF] Cerebral blood flow, cerebral blood volume, and cerebrovascular reactivity after severe head injury

GJ Bouma, JP Muizelaar - J Neurotrauma, 1992 - researchgate.net
Traumatic brain injury (TBI) often causes disturbances of the cerebrovascular circulation,
which contribute to the infliction of secondary injury, although the complex nature of the …

Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study

N Kuppermann, JF Holmes, PS Dayan, JD Hoyle… - The Lancet, 2009 - thelancet.com
Background CT imaging of head-injured children has risks of radiation-induced malignancy.
Our aim was to identify children at very low risk of clinically-important traumatic brain injuries …

Adverse effects of prolonged hyperventilation in patients with severe head injury: a randomized clinical trial

JP Muizelaar, A Marmarou, JD Ward, HA Kontos… - Journal of …, 1991 - thejns.org
✓ There is still controversy over whether or not patients should be hyperventilated after
traumatic brain injury, and a randomized trial has never been conducted. The theoretical …

[HTML][HTML] Lack of effect of induction of hypothermia after acute brain injury

GL Clifton, ER Miller, SC Choi, HS Levin… - … England Journal of …, 2001 - Mass Medical Soc
Background Induction of hypothermia in patients with brain injury was shown to improve
outcomes in small clinical studies, but the results were not definitive. To study this issue, we …

Cerebral circulation and metabolism after severe traumatic brain injury: the elusive role of ischemia

GJ Bouma, JP Muizelaar, SC Choi, PG Newlon… - Journal of …, 1991 - thejns.org
✓ Although experimental and pathological studies suggest an important role for ischemia in
the majority of fatal cases of traumatic brain injury, ischemia has been a rare finding in most …

Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography

GJ Bouma, JP Muizelaar, WA Stringer, SC Choi… - Journal of …, 1992 - thejns.org
✓ The role of cerebral ischemia in the pathophysiology of traumatic brain injury is unclear.
Cerebral blood flow (CBF) measurements with 133 Xe have thus far revealed ischemia in a …

Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children

PD Adelson, J Ragheb, JP Muizelaar, P Kanev… - …, 2005 - journals.lww.com
OBJECTIVE: To determine whether moderate hypothermia (HYPO)(32–33 C) begun in the
early period after severe traumatic brain injury (TBI) and maintained for 48 hours is safe …

Mannitol causes compensatory cerebral vasoconstriction and vasodilation in response to blood viscosity changes

JP Muizelaar, EP Wei, HA Kontos, DP Becker - Journal of neurosurgery, 1983 - thejns.org
✓ There is no proof that osmotic agents such as mannitol lower intracranial pressure (ICP)
by decreasing brain water content. An alternative mechanism might be a reduction in …