Background: Among patients with a patent foramen ovale (PFO) and a prior cryptogenic
ischemic stroke or TIA, the absolute and relative risk of recurrent events is unclear. Methods …

Background Nerinetide, an eicosapeptide that interferes with post-synaptic density protein
95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia …

Background Intravenous thrombolysis with alteplase bolus followed by infusion is a global
standard of care for patients with acute ischaemic stroke. We aimed to determine whether …

Abstract Purpose of Review Therapeutic hypothermia (TH) in stroke demonstrates robust
neuroprotection in animals but clinical applications remain controversial. We assessed …

Background and Purpose—We report on workflow and process-based performance
measures and their effect on clinical outcome in Solitaire FR Thrombectomy for Acute …

BACKGROUND AND PURPOSE: Collateral status at baseline is an independent
determinant of clinical outcome among patients with acute ischemic stroke. We sought to …

The advent of mechanical thrombectomy and increasing alteplase use have transformed the
care of patients with acute ischemic stroke. Patients with major arterial occlusions with poor …

Background and Purpose: Available data on the clinical course of patients with acute
ischemic stroke due to medium vessel occlusion (MeVO) are mostly limited to those with M2 …

Rapid reperfusion of the entire territory distal to vascular occlusions is the aim of stroke
interventions. Recent studies defined successful reperfusion as establishing some perfusion …

Background Follow-up infarct volume (FIV) has been recommended as an early indicator of
treatment efficacy in patients with acute ischemic stroke. Questions remain about the optimal …