Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large
vessel occlusion and has recently revolutionized stroke care. Oftentimes, ischemic core …

The majority of existing medical diagnosis depends on the blood analysis in centralized
sophisticated laboratories having bulky, complex, and time-consuming clinical instruments …

Abdominal computed tomography (CT) is frequently performed to evaluate gastrointestinal
pathologic conditions, and the majority of the gastrointestinal radiology literature has …

We adopted a rational approach to design cationic lipids for use in formulations to deliver
small interfering RNA (siRNA). Starting with the ionizable cationic lipid 1, 2-dilinoleyloxy-3 …

The safe and effective delivery of RNA interference (RNAi) therapeutics remains an
important challenge for clinical development. The diversity of current delivery materials …

RNA interference (RNAi) is a ubiquitous and highly effective biological mechanism to control
gene expression. Over the last few years it has been established that synthetic …

Lipid nanoparticles (LNPs) have proven to be highly efficient carriers of short-interfering
RNAs (siRNAs) to hepatocytes in vivo; however, the precise mechanism by which this …

Cholesterol-conjugated siRNAs can silence gene expression in vivo. Here we synthesize a
variety of lipophilic siRNAs and use them to elucidate the requirements for siRNA delivery in …

Nanoparticles are used for delivering therapeutics into cells,. However, size, shape, surface
chemistry and the presentation of targeting ligands on the surface of nanoparticles can affect …

The regulatory approval of Onpattro, a lipid nanoparticle-based short interfering RNA drug
for the treatment of polyneuropathies induced by hereditary transthyretin amyloidosis, paves …