User profiles for "author:Mark Brooks"

Mark Adrian Brooks

Project Leader, Evotec
Verified email at evotec.com
Cited by 575

[PDF][PDF] Peering into the black box of artificial intelligence: evaluation metrics of machine learning methods

GS Handelman, HK Kok, RV Chandra… - American Journal of …, 2019 - Am Roentgen Ray Soc
OBJECTIVE. Machine learning (ML) and artificial intelligence (AI) are rapidly becoming the
most talked about and controversial topics in radiology and medicine. Over the past few …

[HTML][HTML] Endovascular therapy for ischemic stroke with perfusion-imaging selection

BCV Campbell, PJ Mitchell, TJ Kleinig… - … England Journal of …, 2015 - Mass Medical Soc
Background Trials of endovascular therapy for ischemic stroke have produced variable
results. We conducted this study to test whether more advanced imaging selection, recently …

A review of the management of cerebral vasospasm after aneurysmal subarachnoid hemorrhage

K Li, CD Barras, RV Chandra, HK Kok, JT Maingard… - World neurosurgery, 2019 - Elsevier
Background Despite decades of research, cerebral vasospasm (CV) continues to account
for high morbidity and mortality in patients who survive their initial aneurysmal subarachnoid …

[HTML][HTML] Tenecteplase versus alteplase before thrombectomy for ischemic stroke

BCV Campbell, PJ Mitchell, L Churilov… - … England Journal of …, 2018 - Mass Medical Soc
Background Intravenous infusion of alteplase is used for thrombolysis before endovascular
thrombectomy for ischemic stroke. Tenecteplase, which is more fibrin-specific and has …

Review of deep learning algorithms for the automatic detection of intracranial hemorrhages on computed tomography head imaging

M Yeo, B Tahayori, HK Kok, J Maingard… - Journal of …, 2021 - jnis.bmj.com
Artificial intelligence is a rapidly evolving field, with modern technological advances and the
growth of electronic health data opening new possibilities in diagnostic radiology. In recent …

Effect of intravenous tenecteplase dose on cerebral reperfusion before thrombectomy in patients with large vessel occlusion ischemic stroke: the EXTEND-IA TNK part …

BCV Campbell, PJ Mitchell, L Churilov, N Yassi… - Jama, 2020 - jamanetwork.com
Importance Intravenous thrombolysis with tenecteplase improves reperfusion prior to
endovascular thrombectomy for ischemic stroke compared with alteplase. Objective To …

A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits with Intra-Arterial therapy (EXTEND …

BCV Campbell, PJ Mitchell, B Yan… - … Journal of Stroke, 2014 - journals.sagepub.com
Background and Hypothesis Thrombolysis with tissue plasminogen activator is proven to
reduce disability when given within 4.5 h of ischemic stroke onset. However, tissue …

Binding mode and structure–activity relationships around direct inhibitors of the Nrf2–Keap1 complex

E Jnoff, C Albrecht, JJ Barker, O Barker… - …, 2014 - Wiley Online Library
An X‐ray crystal structure of Kelch‐like ECH‐associated protein (Keap1) co‐crystallised with
(1S, 2R)‐2‐[(1S)‐1‐[(1, 3‐dioxo‐2, 3‐dihydro‐1H‐isoindol‐2‐yl) methyl]‐1, 2, 3, 4 …

[HTML][HTML] Preoperative assessment of hand circulation by means of Doppler ultrasonography and the modified Allen test

P Ruengsakulrach, M Brooks, DL Hare, I Gordon… - The Journal of thoracic …, 2001 - Elsevier
Objective: The aims of this study were as follows:(1) to evaluate Doppler ultrasonography in
assessing hand collateral circulation;(2) to define the criteria for an abnormal Doppler …

New capabilities of the “SHOALS” airborne lidar bathymeter

GC Guenther, MW Brooks, PE LaRocque - Remote Sensing of …, 2000 - Elsevier
The technology and methodology of airborne laser bathymetry are far from mature, and new
capabilities continue to be attained. The SHOALS lidar system was recently augmented with …